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宫腔内注射富血小板血浆通过增加反复种植失败女性的子宫内膜厚度来改善胚胎着床:一项单臂自身对照试验。

Intrauterine administration of platelet-rich plasma improves embryo implantation by increasing the endometrial thickness in women with repeated implantation failure: A single-arm self-controlled trial.

作者信息

Kusumi Maki, Ihana Tatsuji, Kurosawa Takako, Ohashi Yasuo, Tsutsumi Osamu

机构信息

Center for Human Reproduction and Gynecologic Endoscopy Sanno Hospital Tokyo Japan.

Department of Integrated Science and Engineering for Sustainable Society Chuo University Tokyo Japan.

出版信息

Reprod Med Biol. 2020 Jun 25;19(4):350-356. doi: 10.1002/rmb2.12334. eCollection 2020 Oct.

Abstract

PURPOSE

The purpose of this study was to investigate the effectiveness of intrauterine administration of platelet-rich plasma (PRP) in frozen embryo transfer (FET) cycle in Japanese patients with a thin endometrium.

METHOD

A prospective single-arm self-controlled trial was conducted in Japan. PRP administration was performed in 36 of the 39 eligible patients with a thin endometrium (≤7 mm). Hormone replacement therapy (HRT) with estrogen was performed for 2 menstrual cycles, and PRP was administrated on the 10th and 12th days of the second HRT cycle. The endometrial thickness was evaluated on transvaginal ultrasonography by two physicians at every visit, one an attending physician and the other a specialist physician blinded to the date and timing of the sonography. FET was performed during the second HRT cycle after PRP administration.

RESULTS

After PRP administration, the mean (SD) endometrial thickness on the 14th day was significantly increased by 1.27 mm ( < .001) and 0.72 mm ( = .001) on the basis of the unblinded and blinded measurements, respectively. Of the 36 patients, 32 (88.9%) underwent FET. The clinical pregnancy rate was 15.6%. No adverse events occurred.

CONCLUSIONS

PRP therapy was safe and effective in increasing endometrial thickness improving possibly pregnancy rate.

摘要

目的

本研究旨在调查在日本薄子宫内膜患者的冷冻胚胎移植(FET)周期中宫腔内注射富血小板血浆(PRP)的有效性。

方法

在日本进行了一项前瞻性单臂自身对照试验。39例符合条件的薄子宫内膜(≤7毫米)患者中有36例接受了PRP注射。进行了2个月经周期的雌激素激素替代疗法(HRT),并在第二个HRT周期的第10天和第12天注射PRP。每次就诊时由两名医生通过经阴道超声评估子宫内膜厚度,一名是主治医师,另一名是对超声检查日期和时间不知情的专科医生。在注射PRP后的第二个HRT周期进行FET。

结果

注射PRP后,基于未设盲和设盲测量,第14天的平均(标准差)子宫内膜厚度分别显著增加了1.27毫米(P<0.001)和0.72毫米(P=0.001)。36例患者中有32例(88.9%)进行了FET。临床妊娠率为15.6%。未发生不良事件。

结论

PRP治疗在增加子宫内膜厚度并可能提高妊娠率方面是安全有效的。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb10/7542012/f8a09d32b524/RMB2-19-350-g001.jpg

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