Department of Internal Medicine, Cardinal Santos Medical Center, San Juan, Metro Manila, Philippines.
Department of Pathology, College of Medicine, University of the Philippines Manila, Metro Manila, Philippines.
J ASEAN Fed Endocr Soc. 2022;37(1):103-106. doi: 10.15605/jafes.037.01.18. Epub 2022 Apr 20.
A lateral neck mass can be the initial presentation of a papillary thyroid carcinoma. A 24-year-old female presented with a 2.0 x 2.0 cm, non-erythematous, non-tender, right lateral neck mass. A neck ultrasound showed an enlarged right jugulodigastric (Level II) lymph node and a normal-sized thyroid gland exhibiting mild parenchymal disease with no nodules. Positron emission tomography-computed tomography scan (PET-CT) showed an enlarged intensely fluorodeoxyglucose (FDG)-avid right level III lymph node, which may be primary versus metastatic. Fine-needle aspiration biopsy (FNAB) of the lymph node showed the presence of atypical cells that are highly suspicious for metastatic carcinoma. A cervical lymph node excision biopsy was performed and histopathology showed metastatic papillary thyroid carcinoma. The patient underwent total thyroidectomy with neck dissection. The final histopathologic examination of the thyroid gland revealed chronic lymphocytic thyroiditis with the lymph nodes negative for metastasis. She eventually underwent radioactive iodine ablation (RAI) with a dose of 30mCi. Post-RAI whole-body scan showed functioning thyroid tissue remnants with no distant metastasis. This case adds to the limited data that ectopic thyroid carcinoma can be present in patients who initially present with neck masses.
颈侧肿块可作为甲状腺乳头状癌的首发表现。一名 24 岁女性因 2.0 x 2.0 cm 的右侧颈侧非红斑、非触痛肿块就诊。颈部超声显示右侧颈静脉二腹肌(II 级)淋巴结肿大,甲状腺大小正常,实质轻度病变,无结节。正电子发射断层扫描-计算机断层扫描(PET-CT)显示右侧 III 级淋巴结肿大,摄取氟脱氧葡萄糖(FDG)强烈,可能是原发性而非转移性。淋巴结细针抽吸活检(FNAB)显示存在高度疑似转移性癌的异型细胞。进行了颈部淋巴结切除术,组织病理学显示转移性甲状腺乳头状癌。患者接受了甲状腺全切除术和颈部清扫术。甲状腺的最终组织病理学检查显示慢性淋巴细胞性甲状腺炎,淋巴结无转移。她最终接受了 30mCi 的放射性碘消融(RAI)治疗。RAI 后全身扫描显示功能甲状腺组织残留,无远处转移。该病例增加了有限的数据,即异位甲状腺癌可能存在于最初表现为颈部肿块的患者中。