Tsivelekas Konstantinos, Evangelopoulos Dimitrios Stergios, Pallis Dimitrios, Benetos Ioannis S, Papadakis Stamatios A, Vlamis John, Pneumaticos Spyros G
Second Department of Orthopaedics, KAT General Hospital, Athens, GRC.
Third Department of Orthopaedics, National and Kapodistrian University of Athens School of Medicine, KAT General Hospital, Athens, GRC.
Cureus. 2022 May 30;14(5):e25475. doi: 10.7759/cureus.25475. eCollection 2022 May.
Traumatic spinal cord injury (SCI) provokes the onset of an intricate pathological process. Initial primary injury ruptures local micro-neuro-vascularcomplex triggering the commencement of multi-factorial secondary sequences which exert significant influence on neurological deterioration progress. Stimulating by local ischemia, neovascularization pathways emerge to provide neuroprotection and improve functional recovery. Although angiogenetic processes are prompted, newly formed vascular system is frequently inadequate to distribute sufficient blood supply and improve axonal recovery. Several treatment interventions have been endeavored to achieve the optimal conditions in SCI microenvironment, enhancing angiogenesis and improve functional recovery. In this study we review the revascularization pathogenesis and importance within the secondary processes and condense the proangiogenic influence of several angiogenetic-targeted treatment interventions.
创伤性脊髓损伤（SCI）引发了一个复杂的病理过程。最初的原发性损伤会使局部微神经血管复合体破裂，从而引发多因素继发性反应的开始，这些反应对神经功能恶化进程有重大影响。在局部缺血的刺激下，新血管生成途径出现以提供神经保护并促进功能恢复。尽管血管生成过程被激发，但新形成的血管系统往往不足以提供足够的血液供应并促进轴突恢复。人们已经尝试了几种治疗干预措施，以在SCI微环境中实现最佳条件，增强血管生成并促进功能恢复。在本研究中，我们回顾了再血管化的发病机制及其在继发性过程中的重要性，并总结了几种血管生成靶向治疗干预措施的促血管生成作用。
