疾病持续时间会影响精神分裂症阴性症状的严重程度吗？
Does the Duration of the Illness Affect the Severity of Negative Symptoms of Schizophrenia?
作者信息
Becarevic Nejra, Softic Rusmir, Osmanovic Enes
机构信息
Clinic of Psychiatry, University Clinical Center Tuzla, Bosnia and Herzegovina.
Faculty of Medicine, University of Tuzla, Bosnia and Herzegovina.
出版信息
Mater Sociomed. 2022 Mar;34(1):25-27. doi: 10.5455/msm.2022.33.25-27.
BACKGROUND
The negative symptoms of schizophrenia are less known aspects of the illness although they often mark its course and outcome. Negative symptoms refer to loss of function, and they are associated with poor outcomes. It is considered that they are more prominent with the longer duration of illness.
OBJECTIVE
To determine the negative symptoms in the patients with schizophrenia with regard to the duration of illness.
METHODS
A cross-sectional study was conducted in 60 consecutive outpatients with schizophrenia. Two groups were formed regarding the duration of illness (⩽2 years, and >3 years). The negative symptoms were established with the Brief Negative Symptom Assessment - BNSA.
RESULTS
Average score of negative symptoms in the group with the shorter duration of illness was 8.37±2.94, and in the group with longer duration was 10.73±2.86. Independent Samples Test was significant p=0.003, t-2.367, and therefore the difference between scores on BNSA within groups was significant. Moderate size effect was found (p = 0.69).
CONCLUSION
Negative symptoms of schizophrenia are more prominent with the longer duration of illness.
背景
精神分裂症的阴性症状是该疾病鲜为人知的方面，尽管它们常常标志着疾病的进程和转归。阴性症状指功能丧失，且与不良预后相关。一般认为，随着病程延长，阴性症状会更加突出。
目的
确定精神分裂症患者的阴性症状与病程的关系。
方法
对60例连续就诊的精神分裂症门诊患者进行横断面研究。根据病程（≤2年和>3年）分为两组。采用简明阴性症状评估量表（BNSA）评估阴性症状。
结果
病程较短组的阴性症状平均评分为8.37±2.94，病程较长组为10.73±2.86。独立样本检验显示差异有统计学意义（p = 0.003，t = -2.367），因此两组间BNSA评分差异显著。发现效应量中等（p = 0.69）。
结论
精神分裂症的阴性症状随病程延长而更加突出。
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