Thara R, Henrietta M, Joseph A, Rajkumar S, Eaton W W
Schizophrenia Research Foundation, Madras, India.
Acta Psychiatr Scand. 1994 Nov;90(5):329-36. doi: 10.1111/j.1600-0447.1994.tb01602.x.
Ninety first-episode patients fulfilling ICD-9 criteria for schizophrenia were followed up prospectively for 10 years. Complete assessments were possible on 76. The pattern of illness was good in 67% of the cases, and the commonest patterns was one with recurrent episodes. Predictors of poor course and longer time spent in psychosis were identified. All positive and negative symptoms showed a steep decline at the end of 10 years. The results are discussed in the context of longitudinal research on the course of schizophrenia in developing countries.
90例符合国际疾病分类第九版（ICD - 9）精神分裂症标准的首发患者接受了为期10年的前瞻性随访。其中76例患者能够完成全面评估。67%的病例病情模式良好，最常见的模式是复发发作。确定了病程不良和精神病发作时间较长的预测因素。在10年末，所有阳性和阴性症状均急剧下降。本文在发展中国家精神分裂症病程纵向研究的背景下对结果进行了讨论。
