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Use of cognitive remediation to treat negative symptoms in schizophrenia: is it time yet?使用认知矫正治疗精神分裂症阴性症状:时机是否已到?
Br J Psychiatry. 2023 Jul;223(1):319-320. doi: 10.1192/bjp.2023.50.
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Real-life functioning in women with schizophrenia living in residential facilities: Gender-based comparison.居住在寄宿机构的精神分裂症女性的现实生活功能:基于性别的比较。
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Premorbid adjustment associates with cognitive and functional deficits in individuals at ultra-high risk of psychosis.病前适应与处于超高精神分裂症风险个体的认知和功能缺陷相关。
Schizophrenia (Heidelb). 2022 Oct 7;8(1):79. doi: 10.1038/s41537-022-00285-1.
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Psychometric Properties of the Montreal Cognitive Assessment (MoCA) to Detect Major Neurocognitive Disorder Among Older People in Ethiopia: A Validation Study.蒙特利尔认知评估量表(MoCA)用于检测埃塞俄比亚老年人中重度神经认知障碍的心理测量学特性:一项验证研究。
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马来西亚一家精神病院长期住院精神分裂症患者心理社会功能的预测因素

Predictors of Psychosocial Functioning Among Long-stay Schizophrenia Patients in a Malaysian Mental Institution.

作者信息

Teo Pey Fang, Koh Eugene Boon Yau, Chong Seng Choi

机构信息

Department of Psychiatry, Hospital Pakar Sultanah Fatimah, Johor, Malaysia.

Department of Psychiatry, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Selangor, Malaysia.

出版信息

Malays J Med Sci. 2024 Dec;31(6):178-193. doi: 10.21315/mjms2024.31.6.14. Epub 2024 Dec 31.

DOI:10.21315/mjms2024.31.6.14
PMID:39830103
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11740817/
Abstract

BACKGROUND

A considerable number of schizophrenia patients still require long-term hospital care despite psychiatric deinstitutionalisation, especially in developing nations. Prolonged hospitalisation is associated with greater impairment in psychosocial functioning. This study aimed to determine the level of psychosocial functioning and its predictors among long-stay schizophrenia patients in a Malaysian mental institution.

METHODS

This cross-sectional study included 138 patients selected through universal sampling. Data on socio-demographics, illness characteristics such as psychopathology and illness severity [measured using the Brief Psychiatric Rating Scale (BPRS)], and cognitive function [assessed using the Montreal Cognitive Assessment (MoCA)] were collected. The Personal and Social Performance (PSP) scale was used to evaluate psychosocial functioning. Pearson correlation coefficients and multiple linear regression analyses were applied to identify the correlates and predictors of psychosocial functioning.

RESULTS

This study found that 47.8% and 16.7% of the patients had moderate and severe cognitive impairments, respectively. The mean PSP score was 69.68 (standard deviation (SD) = 15.48). Female gender, previous unemployment and more severe cognitive impairments were significantly associated with poorer psychosocial functioning. Meanwhile, negative symptoms and age of onset were negatively correlated with psychosocial functioning. By contrast, the duration of illness was positively correlated with psychosocial functioning. The regression model indicated that being female (β = -7.32, < 0.001), previously unemployed (β = -3.67, < 0.047), having negative symptoms (β = -4.18, < 0.001), experiencing a longer illness duration (β = -0.60, = 0.004), and the presence of severe cognitive impairment (β = -9.80, < 0.001) significantly predicted poorer psychosocial functioning.

CONCLUSION

Long-stay schizophrenia patients experience substantial difficulties in psychosocial functioning. Factors such as gender, last employment status, negative symptoms, illness duration, and cognitive function affect psychosocial functioning.

摘要

背景

尽管进行了精神科去机构化治疗,但仍有相当数量的精神分裂症患者需要长期住院治疗,尤其是在发展中国家。长期住院与心理社会功能的更大损害有关。本研究旨在确定马来西亚一家精神病院中长期住院的精神分裂症患者的心理社会功能水平及其预测因素。

方法

本横断面研究通过整群抽样选取了138名患者。收集了社会人口统计学数据、疾病特征(如精神病理学和疾病严重程度[使用简明精神病评定量表(BPRS)测量])以及认知功能[使用蒙特利尔认知评估量表(MoCA)评估]。使用个人和社会表现(PSP)量表来评估心理社会功能。采用Pearson相关系数和多元线性回归分析来确定心理社会功能的相关因素和预测因素。

结果

本研究发现,分别有47.8%和16.7%的患者存在中度和重度认知障碍。PSP量表的平均得分为69.68(标准差(SD)=15.48)。女性、既往失业以及更严重的认知障碍与较差的心理社会功能显著相关。同时,阴性症状和发病年龄与心理社会功能呈负相关。相比之下,病程与心理社会功能呈正相关。回归模型表明,女性(β=-7.32,<0.001)、既往失业(β=-3.67,<0.047)、存在阴性症状(β=-4.18,<0.001)、病程较长(β=-0.60,=0.004)以及存在严重认知障碍(β=-9.80,<0.001)显著预测了较差的心理社会功能。

结论

长期住院的精神分裂症患者在心理社会功能方面存在重大困难。性别、上次就业状况、阴性症状、病程和认知功能等因素会影响心理社会功能。