College of Medicine, QU Health, Qatar University, Doha, Qatar.
Medicine (Baltimore). 2022 Jul 8;101(27):e29401. doi: 10.1097/MD.0000000000029401.
Since SARS-CoV-2 infection was first discovered in December 2019 in Wuhan City in China, it spread rapidly and a global pandemic of COVID-19 has occurred. According to several recent studies on SARS-CoV-2, the virus primarily infects the respiratory system but may cause damage to other systems. ACE-2, the main receptor for entry into the target cells by SARS-CoV-2, was reported to abundantly express in testes, including spermatogonia, Leydig and Sertoli cells. Nevertheless, there is no clinical evidence in the literature about whether SARS-CoV-2 infection has an impact on male reproductive health. Therefore, this review highlights the effect of SARA-CoV-2 infection on male reproductive health, including the reproductive system and its functioning, as well as gamete and male gonadal function that might be affected by the virus itself or secondary to immunological and inflammatory response, as well as drug treatments and the psychological stress related to panic during the COVID-19 outbreak.
自 2019 年 12 月在中国武汉市首次发现 SARS-CoV-2 感染以来，该病毒迅速传播，导致 COVID-19 全球大流行。根据最近几项关于 SARS-CoV-2 的研究，该病毒主要感染呼吸系统，但也可能对其他系统造成损害。ACE-2 是 SARS-CoV-2 进入靶细胞的主要受体，据报道在睾丸中大量表达，包括精原细胞、Leydig 和 Sertoli 细胞。然而，文献中没有关于 SARS-CoV-2 感染是否会影响男性生殖健康的临床证据。因此，本综述强调了 SARS-CoV-2 感染对男性生殖健康的影响，包括生殖系统及其功能，以及可能受到病毒本身或免疫和炎症反应、药物治疗以及与 COVID-19 爆发相关的恐慌相关的心理压力影响的配子和男性性腺功能。
