Unit of Reproductive Endocrinology, 1st Department of Obstetrics and Gynecology, Aristotle University of Thessaloniki Medical School, Papageorgiou Gneral Hospital, 56429 Thessaloniki, Greece.
Unit of Endocrinology, Diabetes and Metabolism, Thyroid Section, Evgenideion Hospital, University of Athens, 20 Papadiamantopoulou Str., 11528 Athens, Greece.
Int J Environ Res Public Health. 2022 Apr 26;19(9):5277. doi: 10.3390/ijerph19095277.
Over 300 million patients with coronavirus disease 2019 (COVID-19) have been reported worldwide since the outbreak of the pandemic in Wuhan, Hubei Province, China. COVID-19 is induced by the acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The effect of SARS-CoV-2 infection on the male reproductive system is unclear. The aim of this review is to assess the effect of SARS-CoV-2 infection on male fertility and the impact of possible mediators, such as metabolic, oxidative and psychological stress. SARS-CoV-2 infection aggravates metabolic stress and directly or indirectly affects male fertility by reducing seminal health. In addition, SARS-CoV-2 infection leads to excessive production of reactive oxygen species (ROS) and increased psychological distress. These data suggest that SARS-CoV-2 infection reduces male fertility, possibly by means of metabolic, oxidative and psychological stress. Therefore, among other consequences, the possibility of COVID-19-induced male infertility should not be neglected.
自 2019 年冠状病毒病（COVID-19）疫情在中国湖北省武汉市爆发以来，全球已报告超过 3 亿例 COVID-19 病例。COVID-19 是由急性呼吸综合征冠状病毒 2（SARS-CoV-2）引起的。SARS-CoV-2 感染对男性生殖系统的影响尚不清楚。本综述的目的是评估 SARS-CoV-2 感染对男性生育能力的影响，以及代谢、氧化和心理压力等可能的介导因素的影响。SARS-CoV-2 感染加重代谢应激，并通过降低精液健康直接或间接地影响男性生育能力。此外，SARS-CoV-2 感染导致活性氧（ROS）过度产生和心理困扰增加。这些数据表明，SARS-CoV-2 感染降低了男性生育能力，可能是通过代谢、氧化和心理压力。因此，除其他后果外，不应忽视 COVID-19 引起的男性不育的可能性。
