Department of Chemistry and Biochemistry, University of California, Los Angeles, California 90095, United States.
Department of Molecular and Medical Pharmacology and Crump Institute for Molecular Imaging, David Geffen School of Medicine, University of California, Los Angeles, California 90095, United States.
Org Lett. 2022 Jul 22;24(28):5132-5136. doi: 10.1021/acs.orglett.2c01965. Epub 2022 Jul 8.
The F labeling of unprotected peptides and sugars with a Au(III)-[F]fluoroaryl complex is reported. The chemoselective method generates F-labeled -aryl bioconjugates in an aqueous environment in 15 min with high radiochemical yields and displays excellent functional group tolerance. This approach utilizes an air and moisture stable, robust organometallic Au(III) complex and highlights the versatility of designer organometallic reagents as efficient agents for rapid radiolabeling.
报道了一种使用 Au(III)-[F]氟芳基配合物对未保护的肽和糖进行 F 标记的方法。该化学选择性方法在 15 分钟内以高放射化学产率在水相环境中生成 F 标记的芳基生物缀合物，并显示出极好的官能团耐受性。该方法利用了一种空气和水分稳定、坚固的有机金属 Au(III)配合物，并强调了设计有机金属试剂作为快速放射性标记的有效试剂的多功能性。
