Ofori-Adjei D, Ericsson O, Lindström B, Hermansson J, Adjepon-Yamoah K, Sjöqvist F
Ther Drug Monit. 1986;8(4):457-61. doi: 10.1097/00007691-198612000-00014.
An enantioselective high-performance liquid chromatographic method for chloroquine and desethylchloroquine was developed using a chiral alpha 1-acid glycoprotein column. This method was used to determine concentrations of chloroquine and desethylchloroquine enantiomers in plasma and urine from volunteers given single oral doses of racemic chloroquine. The disposition of the enantiomers was different. The renal clearance of the chloroquine enantiomers was indicative of stereoselective renal secretion of the drug, and evidence for stereoselective metabolism also was found.
建立了一种使用手性α1-酸性糖蛋白柱的对映体选择性高效液相色谱法来测定氯喹和去乙基氯喹。该方法用于测定给予单剂量消旋氯喹的志愿者血浆和尿液中氯喹和去乙基氯喹对映体的浓度。对映体的处置情况不同。氯喹对映体的肾清除率表明该药物存在立体选择性肾分泌，并且还发现了立体选择性代谢的证据。
