Department of Internal Medicine, Jeju National University, College of Medicine, Jeju, South Korea.
Department of Microbiology, Hanyang University College of Medicine, Seoul, South Korea.
Int J Infect Dis. 2022 Sep;122:656-658. doi: 10.1016/j.ijid.2022.06.058. Epub 2022 Jul 5.
We report the administration of an anti-interleukin (IL)-6 antibody in a case of severe fever with thrombocytopenia syndrome (SFTS) with an increase in IL-6. On the day of admission, SFTS viral load and IL-6 concentration were 93 831 copies/ml and 5.4 pg/ml, respectively, and tocilizumab was administered. SFTS viral load decreased to 17 821.1 copies/ml on the 3 day of admission, while IL-6 levels increased to 104.9 pg/ml; SFTS viral load and IL-6 levels had decreased to 2876.4 copies/ml and 48.2 pg/ml on 7 day of admission, respectively. The patient fully recovered no tocilizumab adverse events.
我们报告了一例重症发热伴血小板减少综合征（SFTS）患者在白细胞介素（IL）-6 升高时使用抗 IL-6 抗体治疗的情况。入院当天，SFTS 病毒载量和 IL-6 浓度分别为 93831 拷贝/ml 和 5.4pg/ml，并给予托珠单抗治疗。入院第 3 天 SFTS 病毒载量降至 17821.1 拷贝/ml，而 IL-6 水平升高至 104.9pg/ml；入院第 7 天 SFTS 病毒载量和 IL-6 水平分别降至 2876.4 拷贝/ml 和 48.2pg/ml。患者完全康复，无托珠单抗不良反应。
