剖析超级增强子异质性：是否需要重新审视癌症亚型？

Dissecting super-enhancer heterogeneity: time to re-examine cancer subtypes?

机构信息

Department of Surgery, The Chinese University of Hong Kong, Hong Kong, SAR, China; Jockey Club College of Veterinary Medicine and Life Sciences, City University of Hong Kong, Hong Kong, SAR, China.

State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Nanjing, China.

出版信息

Trends Genet. 2022 Dec;38(12):1199-1203. doi: 10.1016/j.tig.2022.06.006. Epub 2022 Jul 5.

DOI:10.1016/j.tig.2022.06.006

PMID:35803787

Abstract

The heterogeneity of transcriptional regulations by super-enhancers (SEs) is poorly understood in human cancers. Herein, we summarize a bioinformatics workflow for genome-wide SE profiling and identification of subtype-specific SEs and regulatory networks. Dissecting SE heterogeneity provides new insights into cancer biology and alternative therapeutic strategies for cancer precision medicine.

摘要

超级增强子 (SE) 转录调控的异质性在人类癌症中尚未得到充分理解。在此，我们总结了一种用于全基因组 SE 分析和鉴定亚型特异性 SE 及调控网络的生物信息学工作流程。剖析 SE 的异质性为癌症生物学提供了新的见解，并为癌症精准医学提供了新的治疗策略。