花生四烯酸环氧化酶：人尿液中环氧二十碳三烯酸的检测
Arachidonic acid epoxygenase: detection of epoxyeicosatrienoic acids in human urine.
作者信息
Toto R, Siddhanta A, Manna S, Pramanik B, Falck J R, Capdevila J
出版信息
Biochim Biophys Acta. 1987 Jun 2;919(2):132-9. doi: 10.1016/0005-2760(87)90199-8.
PMID:3580381
Abstract
Epoxyeicosatrienoic acids, metabolites of the cytochrome P-450-mediated epoxygenase reaction, were detected in human urine by gas chromatographic-mass spectroscopic techniques after conversion to their hydrogenated and non-hydrogenated methyl and pentafluorobenzyl esters. Initial analysis of the regioisomeric composition utilizing the corresponding hydrogenated pentafluorobenzyl esters revealed the presence of the 8,9- and 14,15-isomers.
摘要
通过气相色谱 - 质谱技术，在将环氧二十碳三烯酸（细胞色素P - 450介导的环氧化酶反应的代谢产物）转化为其氢化和非氢化的甲基及五氟苄酯后，在人尿液中检测到了这些物质。利用相应的氢化五氟苄酯对区域异构体组成进行的初步分析显示存在8,9 - 异构体和14,15 - 异构体。
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