超声在外阴癌患者腹股沟淋巴结评估中的作用：一项系统评价和荟萃分析

The Role of Ultrasound in the Evaluation of Inguinal Lymph Nodes in Patients with Vulvar Cancer: A Systematic Review and Meta-Analysis.

作者信息

Verri Debora, Moro Francesca, Fragomeni Simona Maria, Zaçe Drieda, Bove Sonia, Pozzati Federica, Gui Benedetta, Scambia Giovanni, Testa Antonia Carla, Garganese Giorgia

机构信息

Gynecology and Breast Care Center, Mater Olbia Hospital, 07026 Olbia, Italy.

Unità di Ginecologia Oncologica, Dipartimento Scienze della Salute della Donna, del Bambino e di Sanità Pubblica, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy.

出版信息

Cancers (Basel). 2022 Jun 23;14(13):3082. doi: 10.3390/cancers14133082.

OBJECTIVE

To determine the efficacy of ultrasound in assessing the inguinal lymph nodes in patients with vulvar cancer.

METHODS

A systematic review of published research up to October 2020 that compares the results of ultrasound to determine groin node status with histology was conducted. All study types that reported primary data on the role of ultrasound in the evaluation of groin lymph nodes in vulvar cancer were included in the systematic review. Data retrieved from the included studies were pooled in random-effects meta-analyses.

RESULTS

After the screening and selection process, eight articles were deemed pertinent for inclusion in the systematic review and meta-analysis. The random-effects model showed a pooled Se of 0.85 (95% CI: 0.81-0.89), Sp of 0.86 (95% CI: 0.81-0.91), PPV of 0.65 (95% CI: 0.54-0.79) and NPV of 0.92 (95% CI: 0.91-0.94). There was a pooled LR+ and LR- of 6.44 (95% CI: 3.72-11.4) and 0.20 (95% CI: 0.14-0.27), respectively. The pooled accuracy was 0.85 (95% CI: 0.80-0.91).

CONCLUSIONS

Although the studies had small sample sizes, this review represents the best summary of the data so far. Ultrasound has revealed high sensitivity and high negative predictive value in the assessment of nodal status in vulvar cancer.

目的

确定超声评估外阴癌患者腹股沟淋巴结的疗效。

方法

对截至2020年10月发表的将超声结果与组织学结果进行比较以确定腹股沟淋巴结状态的研究进行系统评价。系统评价纳入了所有报告超声在外阴癌腹股沟淋巴结评估中作用的原始数据的研究类型。从纳入研究中检索的数据汇总进行随机效应荟萃分析。

结果

经过筛选和选择过程，八篇文章被认为适合纳入系统评价和荟萃分析。随机效应模型显示合并灵敏度为0.85（95%CI：0.81-0.89），特异度为0.86（95%CI：0.81-0.91），阳性预测值为0.65（95%CI：0.54-0.79），阴性预测值为0.92（95%CI：0.91-0.94）。合并阳性似然比和阴性似然比分别为6.44（95%CI：3.72-11.4）和0.20（95%CI：0.14-0.27）。合并准确率为0.85（95%CI：0.80-0.91）。