Stella Giulia Maria, Scialò Filippo, Bortolotto Chandra, Agustoni Francesco, Sanci Vincenzo, Saddi Jessica, Casali Lucio, Corsico Angelo Guido, Bianco Andrea
Department of Internal Medicine and Medical Therapeutics, University of Pavia Medical School, 27100 Pavia, Italy.
Unit of Respiratory Diseases IRCCS Policlinico San Matteo Foundation, Department of Medical Sciences and Infective Diseases, 27100 Pavia, Italy.
Cancers (Basel). 2022 Jun 26;14(13):3131. doi: 10.3390/cancers14133131.
It is well known that lung cancer relies on a number of genes aberrantly expressed because of somatic lesions. Indeed, the lungs, based on their anatomical features, are organs at a high risk of development of extremely heterogeneous tumors due to the exposure to several environmental toxic agents. In this context, the microbiome identifies the whole assemblage of microorganisms present in the lungs, as well as in distant organs, together with their structural elements and metabolites, which actively interact with normal and transformed cells. A relevant amount of data suggest that the microbiota plays a role not only in cancer disease predisposition and risk but also in its initiation and progression, with an impact on patients' prognosis. Here, we discuss the mechanistic insights of the complex interaction between lung cancer and microbiota as a relevant component of the microenvironment, mainly focusing on novel diagnostic and therapeutic objectives.
众所周知，肺癌依赖于一些因体细胞病变而异常表达的基因。事实上，基于其解剖学特征，由于接触多种环境毒性物质，肺部是极易发生高度异质性肿瘤的器官。在这种情况下，微生物群确定了肺部以及远处器官中存在的所有微生物组合，以及它们的结构成分和代谢产物，这些微生物与正常细胞和转化细胞积极相互作用。大量数据表明，微生物群不仅在癌症易感性和风险中起作用，而且在癌症的发生和发展中也起作用，对患者的预后有影响。在此，我们讨论肺癌与微生物群之间复杂相互作用的机制见解，微生物群作为微环境的一个相关组成部分，主要关注新的诊断和治疗目标。
