West China School of Public Health, West China Fourth Hospital, and Healthy Food Evaluation Research Center, Sichuan University, Chengdu 610041, China.
Environmental Engineering Laboratory, Departament d' Enginyeria Quimica, Universitat Rovira i Virgili, Av. Països Catalans 26, 43007 Tarragona, Spain.
Int J Environ Res Public Health. 2022 Jun 27;19(13):7886. doi: 10.3390/ijerph19137886.
Bisphenol A (BPA) is used worldwide and research on the toxicity of BPA has advanced rapidly in the last few decades. This study aimed to evaluate the global scientific output of toxicity of BPA and explore the hot spots and research trends. All available articles related to the toxicity of BPA until 2022 were retrieved from the Web of Science Core Collection database. The VOSviewer, a bibliometric analysis software, was used to analyze the information of included articles, including countries/institutions, international cooperation, journals, citations, and keywords. Among 1644 retrieved articles, 1611 eligible studies were identified for analysis, and the annual publications increased with time in the past three decades. China and the United States were the most active contributors in this field. Chinese Academy of Sciences and the Dow chemical company conducted relatively more research than others about BPA toxicity. The journal "" published the most studies on "BPA toxicity". Before 2015, most research focused on estrogenic activity and the test system mainly utilized animal experiments. However, in recent years, research related to toxic mechanisms of BPA at the cellular level and the toxicity of its analogs have received widespread attention. Considering some critical research gaps, future research on BPA toxicology should probably focus on the molecular biology of toxic mechanism, mixture toxicity, and co-exposure of BPA substitutes. This study will help researchers understand past and current research trends, hot spots, and trends of toxicity studies of BPA and, thus, contribute to further research and risk management of BPA.
双酚 A（BPA）在全球范围内被广泛使用，对 BPA 毒性的研究在过去几十年中迅速发展。本研究旨在评估 BPA 毒性的全球科学产出，并探讨热点和研究趋势。从 Web of Science Core Collection 数据库中检索到截至 2022 年与 BPA 毒性相关的所有可用文章。使用文献计量分析软件 VOSviewer 分析纳入文章的信息，包括国家/机构、国际合作、期刊、引用和关键词。在 1644 篇检索文章中，确定了 1611 篇符合条件的研究进行分析，过去三十年的年度出版物数量随时间增加。中国和美国是该领域最活跃的贡献者。中国科学院和道化学公司在 BPA 毒性方面的研究比其他公司更为深入。期刊“Environmental Health Perspectives”发表了最多关于“BPA 毒性”的研究。在 2015 年之前，大多数研究集中在雌激素活性和测试系统主要利用动物实验。然而，近年来，细胞水平 BPA 毒性机制和其类似物毒性的研究受到了广泛关注。考虑到一些关键的研究差距，未来对 BPA 毒理学的研究可能应该集中在毒性机制的分子生物学、混合物毒性以及 BPA 替代品的共同暴露方面。本研究将帮助研究人员了解 BPA 毒性研究的过去和当前研究趋势、热点和趋势，从而为进一步研究和 BPA 的风险管理做出贡献。
