激活转录因子 5 功能在调节细胞应激和存活中的进展。
Advancements in Activating Transcription Factor 5 Function in Regulating Cell Stress and Survival.
机构信息
Engineering Research Center of Cell & Therapeutic Antibody, Ministry of Education, Shanghai Jiao Tong University College of Pharmacy, Shanghai 200240, China.
Institute of Translational Medicine, Shanghai Jiao Tong University, Shanghai 200240, China.
出版信息
Int J Mol Sci. 2022 Jun 27;23(13):7129. doi: 10.3390/ijms23137129.
Activating transcription factor 5 (ATF5) belongs to the activating transcription factor/cyclic adenosine monophosphate (cAMP) response element-binding protein family of basic region leucine zipper transcription factors. ATF5 plays an important role in cell stress regulation and is involved in cell differentiation and survival, as well as centrosome maintenance and development. Accumulating evidence demonstrates that ATF5 plays an oncogenic role in cancer by regulating gene expressions involved in tumorigenesis and tumor survival. Recent studies have indicated that ATF5 may also modify the gene expressions involved in other diseases. This review explores in detail the regulation of ATF5 expression and signaling pathways and elucidates the role of ATF5 in cancer biology. Furthermore, an overview of putative therapeutic strategies that can be used for restoring aberrant ATF5 activity in different cancer types is provided.
激活转录因子 5（ATF5）属于激活转录因子/环磷酸腺苷（cAMP）反应元件结合蛋白家族的碱性亮氨酸拉链转录因子。ATF5 在细胞应激调节中发挥重要作用，参与细胞分化和存活，以及中心体维持和发育。越来越多的证据表明，ATF5 通过调节肿瘤发生和肿瘤存活相关的基因表达，在癌症中发挥致癌作用。最近的研究表明，ATF5 也可能改变其他疾病相关的基因表达。本文详细探讨了 ATF5 表达和信号通路的调控，并阐明了 ATF5 在癌症生物学中的作用。此外，还提供了一种概述，说明了可用于恢复不同癌症类型中异常 ATF5 活性的潜在治疗策略。
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