Department of Philosophy, Social Sciences and Education, University of Perugia, 06126 Perugia, Italy.
Department of Pharmaceutical Sciences, University of Perugia, 06126 Perugia, Italy.
Int J Mol Sci. 2022 Jul 5;23(13):7466. doi: 10.3390/ijms23137466.
The relationship between cholesterol and cancer has been widely demonstrated. Clinical studies have shown changes in blood cholesterol levels in cancer patients. In parallel, basic research studies have shown that cholesterol is involved in the mechanisms of onset and progression of the disease. On the other hand, anorexic patients have high cholesterol levels and a high susceptibility to cancer. In this review, we first present a brief background on the relations among nutrition, eating disorders and cancer. Using several notable examples, we then illustrate the changes in cholesterol in cancer and in anorexia nervosa, providing evidence for their important relationship. Finally, we show a new possible link between cholesterol disorder in cancer and in anorexia nervosa.
胆固醇与癌症之间的关系已得到广泛证实。临床研究表明，癌症患者的血液胆固醇水平发生了变化。与此同时，基础研究表明，胆固醇参与了疾病的发生和发展机制。另一方面，厌食症患者的胆固醇水平较高，且易患癌症。在这篇综述中，我们首先简要介绍了营养、饮食失调和癌症之间的关系。然后，我们使用几个显著的例子来说明癌症和神经性厌食症中胆固醇的变化，为它们之间的重要关系提供了证据。最后，我们展示了癌症和神经性厌食症中胆固醇紊乱之间的新的可能联系。
