Zák A, Vecka M, Tvrzická E, Novák F, Papezová H, Hrubý M, Lubanda H, Stanková B
IV. interní klinika 1. LF UK a VFN, Praha.
Cas Lek Cesk. 2003;142(5):280-4.
Anorexia nervosa is a model of simple starvation accompanied by secondary hyperlipoproteinemia. Plasma fatty acid pattern influences levels of plasma lipids and lipoproteins. Level of plasma lathosterol represents a marker of cholesterol synthesis de novo; levels of plant sterols reflect resorption of exogenous cholesterol. The aim of the study was to evaluate fatty acids in plasma lipid classes and their relationships to plasma lipids, lipoproteins, lathosterol, campesterol and beta-sitosterol.
We examined 16 women with anorexia nervosa and 25 matched controls. Main lipid classes were separated by thin-layer chromatography, fatty acids and non-cholesterol sterols were evaluated by capillary gas chromatography. Patients with anorexia nervosa revealed increased concentrations of total cholesterol, triglycerides, HDL-cholesterol, campesterol and beta-sitosterol; changes in plasma levels of lathosterol did not reach statistical significance. The most consistent finding in fatty acid composition was a decreased content of linoleic acid and raised content of palmitoleic acid in all lipid classes.
Changes of plasma lipids and lipoproteins in anorexia nervosa result from complex mechanisms including increased synthesis of triglyceride-rich lipoproteins along with unchanged cholesterol synthesis rate. Hypercholesterolemia in anorexia nervosa may also result from increased resorption of exogenous cholesterol.
神经性厌食症是一种伴有继发性高脂蛋白血症的单纯饥饿模型。血浆脂肪酸模式会影响血浆脂质和脂蛋白水平。血浆羊毛甾醇水平代表从头合成胆固醇的标志物；植物甾醇水平反映外源性胆固醇的吸收情况。本研究的目的是评估血浆脂质类别中的脂肪酸及其与血浆脂质、脂蛋白、羊毛甾醇、菜油甾醇和β-谷甾醇的关系。
我们检查了16名神经性厌食症女性患者和25名匹配的对照者。主要脂质类别通过薄层色谱法分离，脂肪酸和非胆固醇甾醇通过毛细管气相色谱法评估。神经性厌食症患者的总胆固醇、甘油三酯、高密度脂蛋白胆固醇、菜油甾醇和β-谷甾醇浓度升高；血浆羊毛甾醇水平的变化未达到统计学意义。脂肪酸组成中最一致的发现是所有脂质类别中亚油酸含量降低，棕榈油酸含量升高。
神经性厌食症患者血浆脂质和脂蛋白的变化是由复杂机制引起的，包括富含甘油三酯的脂蛋白合成增加以及胆固醇合成速率不变。神经性厌食症患者的高胆固醇血症也可能源于外源性胆固醇吸收增加。
