Institute of Anatomy, Otto-von-Guericke-University, Leipziger Str. 44, 39120 Magdeburg, Germany.
Department of Dermatology, Otto-von-Guericke-University, Leipziger Str. 44, 39120 Magdeburg, Germany.
Int J Mol Sci. 2022 Jul 5;23(13):7484. doi: 10.3390/ijms23137484.
Inflammatory diseases of the skin, including atopic dermatitis and psoriasis, have gained increasing attention with rising incidences in developed countries over the past decades. While bodily properties, such as immunological responses of the skin, have been described in some detail, interactions with the brain via different routes are less well studied. The suggested routes of the skin-brain axis comprise the immune system, HPA axis, and the peripheral and central nervous system, including microglia responses and structural changes. They provide starting points to investigate the molecular mechanisms of neuropsychiatric comorbidities in AD and psoriasis. To this end, mouse models exist for AD and psoriasis that could be tested for relevant behavioral entities. In this review, we provide an overview of the current mouse models and assays. By combining an extensive behavioral characterization and state-of-the-art genetic interventions with the investigation of underlying molecular pathways, insights into the mechanisms of the skin-brain axis in inflammatory cutaneous diseases are examined, which will spark further research in humans and drive the development of novel therapeutic strategies.
皮肤炎症性疾病，包括特应性皮炎和银屑病，在过去几十年中，在发达国家的发病率不断上升，引起了越来越多的关注。虽然皮肤的身体特性，如免疫反应，已经有了一些详细的描述，但通过不同途径与大脑的相互作用研究得还不够充分。皮肤-大脑轴的建议途径包括免疫系统、HPA 轴以及外周和中枢神经系统，包括小胶质细胞反应和结构变化。它们为研究 AD 和银屑病的神经精神共病的分子机制提供了起点。为此，已经存在用于 AD 和银屑病的小鼠模型，可以对其进行相关行为实体的测试。在这篇综述中，我们提供了当前小鼠模型和检测方法的概述。通过将广泛的行为特征描述和最先进的遗传干预与对潜在分子途径的研究相结合，研究了炎症性皮肤疾病中皮肤-大脑轴的机制，这将激发对人类的进一步研究，并推动新型治疗策略的发展。
