Department of Anesthesiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China; Institute of Anesthesia and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China; Key Laboratory of Anesthesiology and Resuscitation (Huazhong University of Science and Technology), Ministry of Education, China.
Department of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
J Autoimmun. 2024 Apr;144:103176. doi: 10.1016/j.jaut.2024.103176. Epub 2024 Feb 15.
Psoriasis, a chronic inflammatory skin condition, is often accompanied by psychiatric comorbidities such as anxiety, depression, suicidal ideation, and other mental disorders. Psychological disorders may also play a role in the development and progression of psoriasis. The intricate interplay between the skin diseases and the psychiatric comorbidities is mediated by the 'skin-brain axis'. Understanding the mechanisms underlying psoriasis and psychiatric comorbidities can help improve the efficacy of treatment by breaking the vicious cycle of diseases. T cells and related cytokines play a key role in the pathogenesis of psoriasis and psychiatric diseases, and are crucial components of the 'skin-brain axis'. Apart from damaging the blood-brain barrier (BBB) directly, T cells and secreted cytokines could interact with the hypothalamic-pituitary-adrenal axis (HPA axis) and the sympathetic nervous system (SNS) to exacerbate skin diseases or mental disorders. However, few reviews have systematically summarized the roles and mechanisms of T cells in the interaction between psoriasis and psychiatric comorbidities. In this review, we discussed several key T cells and their roles in the 'skin-brain axis', with a focus on the mechanisms underlying the interplay between psoriasis and mental commodities, to provide data that might help develop effective strategies for the treatment of both psoriasis and psychiatric comorbidities.
银屑病是一种慢性炎症性皮肤病，常伴有焦虑、抑郁、自杀意念等精神共病。心理障碍也可能在银屑病的发生和发展中起作用。皮肤病和精神共病之间的复杂相互作用是由“皮肤-大脑轴”介导的。了解银屑病和精神共病的发病机制有助于通过打破疾病的恶性循环来提高治疗效果。T 细胞及相关细胞因子在银屑病和精神疾病的发病机制中起关键作用，是“皮肤-大脑轴”的重要组成部分。T 细胞及其分泌的细胞因子除了直接破坏血脑屏障 (BBB) 外，还可以通过下丘脑-垂体-肾上腺轴 (HPA 轴) 和交感神经系统 (SNS) 与皮肤疾病或精神障碍相互作用，从而加重皮肤疾病或精神障碍。然而，很少有综述系统总结了 T 细胞在银屑病和精神共病相互作用中的作用和机制。在这篇综述中，我们讨论了几种关键的 T 细胞及其在“皮肤-大脑轴”中的作用，重点介绍了银屑病和精神障碍之间相互作用的机制，为开发治疗银屑病和精神共病的有效策略提供了可能有帮助的数据。
