Ridgway J P, Turnbull L W, Smith M A
Br J Radiol. 1987 May;60(713):423-7. doi: 10.1259/0007-1285-60-713-423.
The study of pulsatile cerebrospinal-fluid (CSF) flow may be useful in diagnosis of certain forms of intracranial disease. Previous techniques used to study CSF flow either are invasive or do not allow accurate measurement. Magnetic resonance imaging (MRI) offers a non-invasive method of studying the CSF pathways. Our technique uses MR phase images and allows quantitative measurement of flow velocities and volume-flow rates. Four volunteers were studied at the level of the second cervical vertebra (C2). The MRI pulse sequence was gated from the R-wave of the subject's electrocardiogram and 12 scans were taken corresponding to different times in the cardiac cycle. The variation in flow velocity throughout the cycle was plotted, and maximum caudad and cephalad flow velocities and flow rates were calculated. Good agreement was found between three of the four volunteers. The mean maximum caudad velocity was 2.91 cm s-1 occurring at a mean time of 190 ms after the R-wave. This corresponds to a mean maximum flow rate of 4.13 ml s-1. The total imaging time for each study was about 1 h. Technical developments, allowing simultaneous acquisition of several images throughout the cardiac cycle, will reduce this time significantly.
搏动性脑脊液（CSF）流动的研究可能有助于某些形式颅内疾病的诊断。以前用于研究脑脊液流动的技术要么具有侵入性，要么无法进行精确测量。磁共振成像（MRI）提供了一种研究脑脊液通路的非侵入性方法。我们的技术使用磁共振相位图像，并允许定量测量流速和体积流率。在四名志愿者的第二颈椎（C2）水平进行了研究。MRI脉冲序列由受试者心电图的R波门控，并在心动周期的不同时间进行了12次扫描。绘制了整个周期内流速的变化，并计算了最大尾向和头向流速及流率。在四名志愿者中的三名之间发现了良好的一致性。平均最大尾向速度为2.91 cm s-1，出现在R波后平均190 ms的时间。这对应于平均最大流率为4.13 ml s-1。每次研究的总成像时间约为1小时。技术的发展，允许在整个心动周期同时采集多个图像，将显著减少这个时间。
