Department of Healthcare Administration, College of Medical and Health Science, Asia University, Taichung 41354, Taiwan.
Department of Orthopaedic Surgery, An Nan Hospital, China Medical University, Tainan 40447, Taiwan.
Nutrients. 2022 Jun 23;14(13):2605. doi: 10.3390/nu14132605.
Osteoarthritis (OA) is an age-related disorder that affects the joints and causes functional disability. is a large edible mushroom with several known medicinal functions. However, the therapeutic effects of in OA are unknown. In this study, data from Sprague-Dawley rats with knee OA induced by anterior cruciate ligament transection (ACLT) indicated that mycelium improves ACLT-induced weight-bearing asymmetry and minimizes pain. ACLT-induced increases in articular cartilage degradation and bone erosion were significantly reduced by treatment with mycelium. In addition, mycelium reduced the synthesis of proinflammatory cytokines interleukin-1β and tumor necrosis factor-α in OA cartilage and synovium. mycelium shows promise as a functional food in the treatment of OA.
骨关节炎（OA）是一种与年龄相关的疾病，影响关节并导致功能障碍。 是一种大型食用蘑菇，具有多种已知的药用功能。然而， 对 OA 的治疗效果尚不清楚。在这项研究中，来自前交叉韧带切断（ACLT）诱导的膝骨关节炎的 Sprague-Dawley 大鼠的数据表明，菌丝体改善了 ACLT 诱导的承重不对称，并最大限度地减少了疼痛。用菌丝体治疗可显著降低 ACLT 诱导的关节软骨降解和骨侵蚀的增加。此外，菌丝体减少了 OA 软骨和滑膜中促炎细胞因子白细胞介素-1β和肿瘤坏死因子-α的合成。菌丝体有望成为治疗 OA 的功能性食品。
