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地中海饮食补充杏仁对严重肥胖女性脂肪组织生物学的积极影响。

Positive Effects of a Mediterranean Diet Supplemented with Almonds on Female Adipose Tissue Biology in Severe Obesity.

机构信息

Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Salud Carlos III (ISCIII), 28029 Madrid, Spain.

Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain.

出版信息

Nutrients. 2022 Jun 24;14(13):2617. doi: 10.3390/nu14132617.

DOI:10.3390/nu14132617
PMID:35807797
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9267991/
Abstract

It has been suggested that weight-loss-independent Mediterranean diet benefits on cardiometabolic health and diabetes prevention may be mediated, at least in part, through the modulation of white adipose tissue (WAT) biology. This study aimed to evaluate the short-term effects of a dietary intervention based on the Mediterranean diet supplemented with almonds (MDSA) on the main features of obesity-associated WAT dysfunction. A total of 38 women with obesity were randomly assigned to a 3-month intervention with MDSA versus continuation of their usual dietary pattern. Subcutaneous (SAT) and visceral adipose tissue (VAT) biopsies were obtained before and after the dietary intervention, and at the end of the study period, respectively. MDSA favored the abundance of small adipocytes in WAT. In SAT, the expression of angiogenesis genes increased after MDSA intervention. In VAT, the expression of genes implicated in adipogenesis, angiogenesis, autophagy and fatty acid usage was upregulated. In addition, a higher immunofluorescence staining for PPARG, CD31+ cells and M2-like macrophages and increased ADRB1 and UCP2 protein contents were found compared to controls. Changes in WAT correlated with a significant reduction in circulating inflammatory markers and LDL-cholesterol levels. These results support a protective effect of a Mediterranean diet supplemented with almonds on obesity-related WAT dysfunction.

摘要

有人提出，地中海饮食对心血管代谢健康和糖尿病预防的益处可能与调节白色脂肪组织（WAT）生物学有关，而这种益处与体重减轻无关。本研究旨在评估基于地中海饮食并辅以杏仁的饮食干预对肥胖相关 WAT 功能障碍主要特征的短期影响。共有 38 名肥胖女性被随机分配到为期 3 个月的 MDSA 饮食干预组和继续保持其常规饮食模式组。在饮食干预前后和研究结束时分别获得皮下（SAT）和内脏脂肪组织（VAT）活检。MDSA 有利于 WAT 中小脂肪细胞的丰度增加。在 SAT 中，MDSA 干预后血管生成基因的表达增加。在 VAT 中，与脂肪生成、血管生成、自噬和脂肪酸利用相关的基因表达上调。此外，与对照组相比，PPARG、CD31+细胞和 M2 样巨噬细胞的免疫荧光染色更高，ADRB1 和 UCP2 蛋白含量增加。WAT 的变化与循环炎症标志物和 LDL-胆固醇水平的显著降低相关。这些结果支持地中海饮食辅以杏仁对肥胖相关 WAT 功能障碍的保护作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e608/9267991/a2e8c92fae4f/nutrients-14-02617-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e608/9267991/6933b32891c2/nutrients-14-02617-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e608/9267991/b40e21f23644/nutrients-14-02617-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e608/9267991/f89c0242e4ec/nutrients-14-02617-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e608/9267991/f77de0bebaa5/nutrients-14-02617-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e608/9267991/a2e8c92fae4f/nutrients-14-02617-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e608/9267991/6933b32891c2/nutrients-14-02617-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e608/9267991/b40e21f23644/nutrients-14-02617-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e608/9267991/f89c0242e4ec/nutrients-14-02617-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e608/9267991/f77de0bebaa5/nutrients-14-02617-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e608/9267991/a2e8c92fae4f/nutrients-14-02617-g005.jpg

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