1st Propedeutic Department of Surgery, Aristotle University of Thessaloniki, AHEPA University Hospital, 54636 Thessaloniki, Greece.
Department of Surgery, Aristotle University of Thessaloniki, 54636 Thessaloniki, Greece.
Nutrients. 2022 Jun 24;14(13):2620. doi: 10.3390/nu14132620.
Investigations that focused on the protective role of probiotics against Surgical Site Infections (SSI) in multiple-trauma (MT) patients are generally few, probably due to the complexity of the concept of trauma. We aimed to assess the efficacy of a four-probiotic regime to reduce the incidence of SSI in MT patients, with a brain injury included. MT patients, being intubated and expected to require mechanical ventilation for >10 days, were randomly allocated into placebo (n = 50) or probiotic treatment (n = 53) comprising Lactobacillus acidophilus LA-5 (1.75 × 109 cfu), Lactiplantibacillus plantarum UBLP-40 (0.5 × 109 cfu), Bifidobacterium animalis subsp. lactis BB-12 (1.75 × 109 cfu), and Saccharomycesboulardii Unique-28 (1.5 × 109 cfu) in sachets. All patients received two sachets of placebo or probiotics twice/day for 15 days and were followed-up for 30 days. The operations were classified as neurosurgical, thoracostomies, laparotomies, orthopedics, and others; then, the SSI and the isolated pathogen were registered. A total of 23 (46.0%) and 13 (24.5%) infectious insults in 89 (50 placebo patients) and 88 (53 probiotics-treated) operations (p = 0.022) were recorded, the majority of them relating to osteosynthesis—17 and 8, respectively. The most commonly identified pathogens were Staphylococcus aureus and Acinetobacter baumannii. Our results support published evidence that the prophylactic administration of probiotics in MT patients exerts a positive effect on the incidence of SSI.
针对多发创伤（MT）患者的手术部位感染（SSI）的益生菌保护作用的研究通常很少，这可能是由于创伤概念的复杂性。我们旨在评估四种益生菌方案减少 MT 患者包括脑损伤患者的 SSI 发生率的功效。MT 患者需要插管并预计需要机械通气> 10 天，随机分配到安慰剂（n = 50）或益生菌治疗组（n = 53），益生菌治疗组包括嗜酸乳杆菌 LA-5（1.75×109cfu）、植物乳杆菌 UBLP-40（0.5×109cfu）、动物双歧杆菌亚种 lactis BB-12（1.75×109cfu）和酿酒酵母 Unique-28（1.5×109cfu）。所有患者在 15 天内每天接受两袋安慰剂或益生菌两次，随访 30 天。手术分为神经外科、胸腔切开术、剖腹术、骨科和其他手术；然后记录 SSI 和分离病原体。在 89 例（50 例安慰剂患者）和 88 例（53 例益生菌治疗患者）手术中记录了 23 例（46.0%）和 13 例（24.5%）感染性损伤（p = 0.022），其中大多数与骨合成术有关-分别为 17 例和 8 例。最常见的病原体是金黄色葡萄球菌和鲍曼不动杆菌。我们的结果支持已发表的证据，即 MT 患者预防性给予益生菌对 SSI 的发生率有积极影响。
