Emma Children's Hospital, Amsterdam UMC, Vrije Universiteit, University of Amsterdam, 1081 HV Amsterdam, The Netherlands.
Department of Dietetics, Erasmus MC, Sophia Children's Hospital, Erasmus University, 3015 CN Rotterdam, The Netherlands.
Nutrients. 2022 Jun 30;14(13):2728. doi: 10.3390/nu14132728.
Infant formulas have been designed to mimic human milk for infants who cannot be breastfed. The overall goal is to establish similar functional outcomes to assure optimal growth, development, maturation of the immune system, and programming of the metabolic system. However, after decades of improving infant formula, growth patterns and body composition development are still different in formula-fed infants compared to breastfed infants, which could contribute to an increased risk of obesity among formula-fed infants. It has been hypothesized that the lower protein concentration of breast milk compared to infant formula influences infants' growth and body composition. Thus, several trials in formula-fed infants with different protein intake levels have been performed to test this hypothesis. In this review, we discuss the current evidence on low-protein infant formula and obesity risk, including future perspectives and implications.
婴儿配方奶粉是专为无法母乳喂养的婴儿设计的，以模拟母乳。总体目标是建立类似的功能结果，以确保最佳的生长、发育、免疫系统成熟和代谢系统编程。然而，经过几十年的改进婴儿配方奶粉，与母乳喂养的婴儿相比，配方奶喂养的婴儿的生长模式和身体成分发育仍然不同，这可能导致配方奶喂养的婴儿肥胖风险增加。有人假设，与婴儿配方奶粉相比，母乳中的蛋白质浓度较低会影响婴儿的生长和身体成分。因此，已经在不同蛋白质摄入量的配方奶喂养婴儿中进行了几项试验来检验这一假设。在这篇综述中，我们讨论了低蛋白婴儿配方奶粉和肥胖风险的现有证据，包括未来的前景和影响。
