Abadi Sara Mama, Hammou Habib, Saidi Lidia, Fenni Soumia, Addi Tawfik, Meguenni Ilyes, Negadi Seyf El Islem, Meziane Sahra, Boubred Farid, Landrier Jean-François
Aix-Marseille Univ, INRAE, INSERM, Marseille, C2VN, France.
Laboratory of Physiology of Nutrition and Food, Safety, Department of Biology, Faculty of Natural and Life Sciences, Oran 1 University, Ahmed Ben Bella, Oran, Algeria.
BMC Pregnancy Childbirth. 2025 May 22;25(1):600. doi: 10.1186/s12884-025-07686-x.
Vitamin D is critical in overall health, particularly during pregnancy, as it supports a healthy pregnancy and promotes proper fetal development. This study examined the link between parental 25-hydroxyvitamin D (25(OH)D) deficiency and their offspring's anthropometric and biological parameters.
A cross-sectional study was conducted involving 50 Algerian families, which included 50 pregnant women in their third trimester, 50 fathers, and 50 newborns. Blood samples were collected from both parents and the umbilical cord of the newborns. Serum 25(OH)D concentrations were measured, and demographic and health-related information was gathered from the participants. The anthropometric parameters of the newborns were recorded at birth.
In our study, 16% of women were insufficient in 25(OH)D, 54% were deficient, and the remaining 30% exhibited severe deficiency, with mean 25(OH)D levels of 24.53 ng/ml, 14.23 ng/ml, and 7.69 ng/ml, respectively. Among males, 40% were insufficient, 42% were deficient, and 18% had severe deficiency, with mean 25(OH)D levels of 25 ng/ml, 15.78 ng/ml, and 8.53 ng/ml, respectively. Furthermore, 24% of newborns were insufficient, 52% were deficient, and 24% had severe deficiency, with mean 25(OH)D levels of 23.53 ng/ml, 13.46 ng/ml, and 7.53 ng/ml, respectively. Maternal 25(OH)D levels were positively correlated with the anthropometric parameters of newborns (height, femur length, weight, and Apgar scores at 1 and 5 min after birth). Conversely, paternal deficiency showed no correlation with these parameters.
25(OH)D deficiency significantly impacts newborns and represents a significant risk to their development, whereas paternal deficiency has no impact on the measured anthropometric parameters of newborns.
维生素D对整体健康至关重要，尤其是在孕期，因为它有助于维持健康的妊娠并促进胎儿正常发育。本研究调查了父母25-羟基维生素D（25(OH)D）缺乏与其后代人体测量学和生物学参数之间的联系。
进行了一项横断面研究，涉及50个阿尔及利亚家庭，其中包括50名孕晚期孕妇、50名父亲和50名新生儿。采集了父母及新生儿脐带血样本。测量血清25(OH)D浓度，并收集参与者的人口统计学和健康相关信息。记录新生儿出生时的人体测量学参数。
在我们的研究中，16%的女性25(OH)D水平不足，54%缺乏，其余30%严重缺乏，平均25(OH)D水平分别为24.53 ng/ml、14.23 ng/ml和7.69 ng/ml。男性中，40%不足，42%缺乏，18%严重缺乏，平均25(OH)D水平分别为25 ng/ml、15.78 ng/ml和8.53 ng/ml。此外，24%的新生儿不足，52%缺乏，24%严重缺乏，平均25(OH)D水平分别为23.53 ng/ml、13.46 ng/ml和7.53 ng/ml。母亲的25(OH)D水平与新生儿的人体测量学参数（出生后1分钟和5分钟时的身高、股骨长度、体重和阿氏评分）呈正相关。相反，父亲的维生素D缺乏与这些参数无关。
25(OH)D缺乏对新生儿有显著影响，对其发育构成重大风险，而父亲的维生素D缺乏对所测量的新生儿人体测量学参数没有影响。
