Yuan Muzhaozi, Harnett Mackenzie Caitlin, Yan Tian-Hao, Georgas Elias, Qin Yi-Xian, Zhou Hong-Cai, Wang Ya
J. Mike Walker '66 Department of Mechanical Engineering, Texas A&M University, College Station, TX 77843, USA.
Department of Chemistry, Texas A&M University, College Station, TX 77843, USA.
Nanomaterials (Basel). 2022 Jun 29;12(13):2242. doi: 10.3390/nano12132242.
Finding curable therapies for neurodegenerative disease (ND) is still a worldwide medical and clinical challenge. Recently, investigations have been made into the development of novel therapeutic techniques, and examples include the remote stimulation of nanocarriers to deliver neuroprotective drugs, genes, growth factors, and antibodies using a magnetic field and/or low-power lights. Among these potential nanocarriers, magneto-plasmonic nanoparticles possess obvious advantages, such as the functional restoration of ND models, due to their unique nanostructure and physiochemical properties. In this review, we provide an overview of the latest advances in magneto-plasmonic nanoparticles, and the associated therapeutic approaches to repair and restore brain tissues. We have reviewed their potential as smart nanocarriers, including their unique responsivity under remote magnetic and light stimulation for the controlled and sustained drug delivery for reversing neurodegenerations, as well as the utilization of brain organoids in studying the interaction between NPs and neuronal tissue. This review aims to provide a comprehensive summary of the current progress, opportunities, and challenges of using these smart nanocarriers for programmable therapeutics to treat ND, and predict the mechanism and future directions.
为神经退行性疾病（ND）找到可治愈的疗法仍是一项全球性的医学和临床挑战。最近，人们对新型治疗技术的开发进行了研究，例如利用磁场和/或低功率光远程刺激纳米载体，以递送神经保护药物、基因、生长因子和抗体。在这些潜在的纳米载体中，磁等离子体纳米颗粒具有明显优势，例如由于其独特的纳米结构和物理化学性质，可使ND模型实现功能恢复。在本综述中，我们概述了磁等离子体纳米颗粒的最新进展以及修复和恢复脑组织的相关治疗方法。我们回顾了它们作为智能纳米载体的潜力，包括它们在远程磁和光刺激下的独特响应性，用于可控和持续的药物递送以逆转神经退行性变，以及利用脑类器官研究纳米颗粒与神经元组织之间的相互作用。本综述旨在全面总结使用这些智能纳米载体进行可编程治疗以治疗ND的当前进展、机遇和挑战，并预测其作用机制和未来方向。
