用于脑的多模态影像引导治疗的磁等离子体纳米颗粒的开发。
Development of magneto-plasmonic nanoparticles for multimodal image-guided therapy to the brain.
机构信息
Department of Immunology, Herbert Wertheim College of Medicine, Florida International University, Miami, Florida 33199, USA.
Molecular Imaging Program at Stanford (MIPS), The James H Clark Center, Stanford University, Stanford, California 94305, USA and Department of Radiology, Stanford University School of Medicine, Stanford, California 94305, USA.
出版信息
Nanoscale. 2017 Jan 5;9(2):764-773. doi: 10.1039/c6nr07520g.
Magneto-plasmonic nanoparticles are one of the emerging multi-functional materials in the field of nanomedicine. Their potential for targeting and multi-modal imaging is highly attractive. In this study, magnetic core/gold shell (MNP@Au) magneto-plasmonic nanoparticles were synthesized by citrate reduction of Au ions on magnetic nanoparticle seeds. Hydrodynamic size and optical properties of magneto-plasmonic nanoparticles synthesized with the variation of Au ions and reducing agent concentrations were evaluated. The synthesized magneto-plasmonic nanoparticles exhibited superparamagnetic properties, and their magnetic properties contributed to the concentration-dependent contrast in magnetic resonance imaging (MRI). The imaging contrast from the gold shell part of the magneto-plasmonic nanoparticles was also confirmed by X-ray computed tomography (CT). The transmigration study of the magneto-plasmonic nanoparticles using an in vitro blood-brain barrier (BBB) model proved enhanced transmigration efficiency without disrupting the integrity of the BBB, and showed potential to be used for brain diseases and neurological disorders.
磁等离子体纳米粒子是纳米医学领域中新兴的多功能材料之一。它们在靶向和多模态成像方面的潜力极具吸引力。在这项研究中，通过在磁性纳米粒子种子上还原 Au 离子，合成了磁性核/金壳（MNP@Au）磁等离子体纳米粒子。评估了通过改变 Au 离子和还原剂浓度合成的磁等离子体纳米粒子的水动力尺寸和光学性质。合成的磁等离子体纳米粒子表现出超顺磁性，其磁性有助于磁共振成像（MRI）中浓度依赖性的对比。磁等离子体纳米粒子的金壳部分的成像对比也通过 X 射线计算机断层扫描（CT）得到了证实。通过体外血脑屏障（BBB）模型进行的磁等离子体纳米粒子的迁移研究证明，在不破坏 BBB 完整性的情况下，迁移效率得到了提高，并显示出在治疗脑部疾病和神经紊乱方面的应用潜力。
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