MiWEndo Solutions S.L., 08014 Barcelona, Spain.
Endoscopy Unit, Gastroenterology Department, Hospital Clínic, University of Barcelona, 08036 Barcelona, Spain.
Sensors (Basel). 2022 Jun 29;22(13):4902. doi: 10.3390/s22134902.
This study assesses the efficacy of detecting colorectal cancer precursors or polyps in an ex vivo human colon model with a microwave colonoscopy algorithm. Nowadays, 22% of polyps go undetected with conventional colonoscopy, and the risk of cancer after a negative colonoscopy can be up to 7.9%. We developed a microwave colonoscopy device that consists of a cylindrical ring-shaped switchable microwave antenna array that can be attached to the tip of a conventional colonoscope as an accessory. The accessory is connected to an external unit that allows successive measurements of the colon and processes the measurements with a microwave imaging algorithm. An acoustic signal is generated when a polyp is detected. Fifteen ex vivo freshly excised human colons with cancer ( = 12) or polyps ( = 3) were examined with the microwave-assisted colonoscopy system simulating a real colonoscopy exploration. After the experiment, the dielectric properties of the specimens were measured with a coaxial probe and the samples underwent a pathology analysis. The results show that all the neoplasms were detected with a sensitivity of 100% and specificity of 87.4%.
本研究评估了一种微波结肠镜算法在离体人结肠模型中检测结直肠癌前体或息肉的效果。目前，22%的息肉在常规结肠镜检查中无法被发现，而阴性结肠镜检查后的癌症风险高达 7.9%。我们开发了一种微波结肠镜设备，它由一个圆柱形环形可切换微波天线阵列组成，可以作为附件连接到常规结肠镜的尖端。附件连接到一个外部单元，允许对结肠进行连续测量，并使用微波成像算法处理测量结果。当检测到息肉时会产生一个声学信号。使用微波辅助结肠镜系统模拟真实结肠镜检查对 15 个离体新鲜切除的有癌症（=12）或息肉（=3）的人结肠进行了检查。实验结束后，使用同轴探头测量了标本的介电特性，并且对样本进行了病理分析。结果表明，所有肿瘤的检测灵敏度均为 100%，特异性为 87.4%。
