儿童阻塞性睡眠呼吸暂停的亚型及相关因素。
Subtypes of obstructive sleep apnea in children and related factors.
机构信息
Beijing Key Laboratory of Pediatric Diseases of Otolaryngology, Head, and Neck Surgery, Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China.
Department of Otolaryngology, Head, and Neck Surgery, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China.
出版信息
J Clin Sleep Med. 2022 Oct 1;18(10):2397-2404. doi: 10.5664/jcsm.10124.
STUDY OBJECTIVES
To investigate the prevalence of positional obstructive sleep apnea (P-OSA) and rapid eye movement-related OSA (REM-OSA) in children with OSA and identify related factors.
METHODS
This was a cross-sectional study among children aged 2-12 years diagnosed with OSA using overnight polysomnography (PSG) between August 1, 2020, and July 31, 2021. Demographics, anthropometrics, PSG, and OSA-18 questionnaire data were recorded.
RESULTS
Data from a total of 474 children were available for analysis. Children had a median age of 4.8 (4.1, 6.4) years, 66.7% were male, and 23.2% were obese. The prevalence of P-OSA was 38.2% and that of REM-OSA was 43.0%. P-OSA was correlated with age and obstructive apnea-hypopnea index (OAHI; odds ratio [OR] = 1.172, 0.947; = .005, < 0.001, respectively), but not sex, obesity, and adenoid and tonsil size (OR = 1.265, 0.785, 0.826, 0.989; = .258, 0.327, 0.153, 0.905, respectively). REM-OSA was correlated with age, adenoid size, tonsil size, and OAHI (OR = 0.876, 1.320, 1.387, 1.021; = .024, 0.040, 0.001, 0.042) but not with sex and obesity (OR = 0.910, 1.281; = .643, 0.315).
CONCLUSIONS
The prevalence of P-OSA was 38.2% and that of REM-OSA was 43.0% in children with OSA. Age was correlated with both the prevalence of P-OSA and REM-OSA, with an increasing and decreasing prevalence as children grew older, respectively. The severity of OSA was significantly associated with the prevalence of both P-OSA and REM-OSA. Adenoid and tonsil size were correlated with the prevalence of REM-OSA but not P-OSA. Obesity and sex were not associated with the prevalence of P-OSA or REM-OSA.
CITATION
Wu Y, Zheng L, Cui G, Xu Z, Ni X. Subtypes of obstructive sleep apnea in children and related factors. . 2022;18(10):2397-2404.
研究目的
调查阻塞性睡眠呼吸暂停（OSA）患儿中位置性阻塞性睡眠呼吸暂停（P-OSA）和快速眼动相关 OSA（REM-OSA）的患病率，并确定相关因素。
方法
这是一项横断面研究，纳入 2020 年 8 月 1 日至 2021 年 7 月 31 日期间经整夜多导睡眠图（PSG）诊断为 OSA 的 2-12 岁儿童。记录人口统计学、人体测量学、PSG 和 OSA-18 问卷数据。
结果
共有 474 例儿童的数据可用于分析。儿童的中位年龄为 4.8（4.1，6.4）岁，66.7%为男性，23.2%为肥胖。P-OSA 的患病率为 38.2%，REM-OSA 的患病率为 43.0%。P-OSA 与年龄和阻塞性呼吸暂停低通气指数（OAHI；比值比[OR] = 1.172，0.947； =.005，< 0.001）相关，但与性别、肥胖和腺样体扁桃体大小（OR = 1.265，0.785，0.826，0.989； =.258，0.327，0.153，0.905）无关。REM-OSA 与年龄、腺样体大小、扁桃体大小和 OAHI（OR = 0.876，1.320，1.387，1.021； =.024，0.040，0.001，0.042）相关，但与性别和肥胖无关（OR = 0.910，1.281； =.643，0.315）。
结论
OSA 患儿中 P-OSA 的患病率为 38.2%，REM-OSA 的患病率为 43.0%。年龄与 P-OSA 和 REM-OSA 的患病率均相关，随着儿童年龄的增长，患病率呈增加和降低趋势。OSA 的严重程度与 P-OSA 和 REM-OSA 的患病率显著相关。腺样体扁桃体大小与 REM-OSA 的患病率相关，但与 P-OSA 无关。肥胖和性别与 P-OSA 或 REM-OSA 的患病率无关。
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