快速眼动睡眠相关阻塞性睡眠呼吸暂停患儿陈述性记忆巩固受损。
Impaired declarative memory consolidation in children with REM sleep-related obstructive sleep apnea.
机构信息
Department of Respiratory Medicine, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China.
State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern, Beijing Normal University, Beijing, China.
出版信息
J Clin Sleep Med. 2024 Mar 1;20(3):417-425. doi: 10.5664/jcsm.10892.
STUDY OBJECTIVES
We explored whether declarative memory consolidation is impaired in children with rapid eye movement sleep-related obstructive sleep apnea (REM-OSA) and investigated the correlation between memory consolidation and sleep-related respiratory parameters.
METHODS
Participants were children with habitual snoring aged 6-14 years and control children. Participants underwent polysomnography and declarative memory testing. Participants with snoring were categorized as primary snoring (PS), non-rapid eye movement sleep-related obstructive sleep apnea (NREM-OSA), stage-independent (SI)-OSA, and REM-OSA according to obstructive apnea-hypopnea index (OAHI), OAHI in REM sleep (OAHI), and OAHI in NREM sleep (OAHI). Declarative memory consolidation level was assessed by recall and recognition rates.
RESULTS
There were 34 controls and 228 children with sleep-disordered breathing: 73 PS, 48 NREM-OSA, 59 SI-OSA, and 48 REM-OSA. Total arousal index was lower in the REM-OSA group than in the NREM-OSA group. In all groups, retest scores were higher than immediate test scores. Recall consolidation in PS, SI-OSA, and REM-OSA groups was lower than for controls and lower in REM-OSA than in NREM-OSA. There were no correlations between recall consolidation or recognition consolidation and OAHI, OAHI, oxygen desaturation index in REM sleep, total arousal index, or REM sleep percent. Recognition consolidation was negatively correlated with OAHI.
CONCLUSIONS
Memory consolidation is impaired in children with REM-OSA compared with NREM-OSA and controls. There was no significant correlation between memory consolidation and OAHI, and recognition consolidation was negatively correlated with OAHI. It is important to pay attention to the OSA subtype in children.
CITATION
Tang Y, Yang C, Wang C, Wu Y, Xu Z, Ni X. Impaired declarative memory consolidation in children with REM sleep-related obstructive sleep apnea. . 2024;20(3):417-425.
研究目的
我们探讨了快动眼睡眠相关阻塞性睡眠呼吸暂停（REM-OSA）患儿是否存在陈述性记忆巩固受损，并研究了记忆巩固与睡眠相关呼吸参数之间的相关性。
方法
参与者为 6-14 岁习惯性打鼾的儿童和对照组儿童。参与者接受多导睡眠图和陈述性记忆测试。根据阻塞性呼吸暂停低通气指数（OAHI）、REM 睡眠时的 OAHI（OAHI）和非 REM 睡眠时的 OAHI（OAHI），将打鼾者分为单纯性打鼾（PS）、非 REM 睡眠相关阻塞性睡眠呼吸暂停（NREM-OSA）、与睡眠期无关的阻塞性睡眠呼吸暂停（SI-OSA）和 REM-OSA。通过回忆和识别率评估陈述性记忆巩固水平。
结果
共有 34 名对照组儿童和 228 名患有睡眠呼吸障碍的儿童：73 名 PS、48 名 NREM-OSA、59 名 SI-OSA 和 48 名 REM-OSA。与 NREM-OSA 组相比，REM-OSA 组总觉醒指数较低。在所有组中，重测分数均高于即时测试分数。PS、SI-OSA 和 REM-OSA 组的回忆巩固水平低于对照组，且 REM-OSA 组低于 NREM-OSA 组。回忆巩固和识别巩固与 OAHI、OAHI、REM 睡眠时血氧饱和度下降指数、总觉醒指数或 REM 睡眠百分比均无相关性。识别巩固与 OAHI 呈负相关。
结论
与 NREM-OSA 和对照组相比，REM-OSA 患儿的记忆巩固受损。记忆巩固与 OAHI 之间无显著相关性，识别巩固与 OAHI 呈负相关。在儿童中，注意 OSA 亚型很重要。
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