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人类微生物组在乳腺癌和结肠癌中的串扰:代谢组学分析。

The crosstalk of the human microbiome in breast and colon cancer: A metabolomics analysis.

机构信息

Department of Biomedical Sciences, School of Biosciences and Technology, Vellore Institute of Technology (VIT), Vellore, Tamil Nadu 632014, India.

Department of Integrative Biology, School of Bio Sciences and Technology, Vellore Institute of Technology (VIT), Vellore, Tamil Nadu 632014, India.

出版信息

Crit Rev Oncol Hematol. 2022 Aug;176:103757. doi: 10.1016/j.critrevonc.2022.103757. Epub 2022 Jul 7.

Abstract

The human microbiome's role in colon and breast cancer is described in this review. Understanding how the human microbiome and metabolomics interact with breast and colon cancer is the chief area of this study. First, the role of the gut and distal microbiome in breast and colon cancer is investigated, and the direct relationship between microbial dysbiosis and breast and colon cancer is highlighted. This work also focuses on the many metabolomic techniques used to locate prospective biomarkers, make an accurate diagnosis, and research new therapeutic targets for cancer treatment. This review clarifies the influence of anti-tumor medications on the microbiota and the proactive measures that can be taken to treat cancer using a variety of therapies, including radiotherapy, chemotherapy, next-generation biotherapeutics, gene-based therapy, integrated omics technology, and machine learning.

摘要

本文综述了人类微生物组在结肠癌和乳腺癌中的作用。本研究的主要领域是了解人类微生物组和代谢组学如何与乳腺癌和结肠癌相互作用。首先,研究了肠道和远端微生物组在乳腺癌和结肠癌中的作用,并强调了微生物失调与乳腺癌和结肠癌之间的直接关系。这项工作还侧重于许多代谢组学技术,用于寻找有前景的生物标志物、进行准确诊断,并研究癌症治疗的新治疗靶点。本综述阐明了抗肿瘤药物对微生物群的影响,以及可以采取的积极措施,通过多种疗法治疗癌症,包括放疗、化疗、下一代生物疗法、基于基因的治疗、综合组学技术和机器学习。

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