The First Affiliated Hospital, Department of Rheumatology, Hengyang Medical School, University of South China, 421001, Hengyang, Hunan, China.
Institute of Pathogenic Biology and Key Laboratory of Special Pathogen Prevention and Control of Hunan Province, Hengyang Medical School, University of South China, 421001, Hengyang, Hunan, China.
Mol Biol Rep. 2022 Nov;49(11):10761-10773. doi: 10.1007/s11033-022-07669-7. Epub 2022 Jul 9.
Autophagy is a lysosomal degradation pathway that depends on various evolutionarily conserved autophagy-related genes (ATGs). Dysregulation of autophagy plays an important role in the occurrence and development of cancer. Chemotherapy, targeted therapy, radiotherapy, and immunotherapy are important treatment options for cancer, which can significantly improve the survival rate of cancer patients. However, the occurrence of therapy resistance results in therapeutic failure and poor prognosis of cancer. Accumulating studies have found that long non-coding RNAs (lncRNAs) are well known as crucial regulators to control autophagy through regulating ATGs and autophagy-associated signaling pathways, including the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) signaling pathway, ultimately mediating chemoresistance and radioresistance. Taken together, this review systematically summarizes and elucidates the pivotal role of lncRNAs in cancer chemoresistance and radioresistance via regulating autophagy. Understanding the specific mechanism of which may provide autophagy-related therapeutic targets for cancer in the future.
自噬是一种依赖于各种进化上保守的自噬相关基因（ATGs）的溶酶体降解途径。自噬的失调在癌症的发生和发展中起着重要作用。化疗、靶向治疗、放疗和免疫治疗是癌症的重要治疗选择，可显著提高癌症患者的生存率。然而，治疗耐药的发生导致治疗失败和癌症预后不良。越来越多的研究发现，长链非编码 RNA（lncRNA）是通过调节 ATGs 和自噬相关信号通路，包括磷脂酰肌醇 3-激酶（PI3K）/蛋白激酶 B（AKT）/雷帕霉素靶蛋白（mTOR）信号通路，来控制自噬的关键调节因子，最终介导化疗耐药和放疗耐药。总之，本综述系统地总结和阐明了 lncRNA 通过调节自噬在癌症化疗耐药和放疗耐药中的关键作用。了解其具体机制可能为未来癌症的自噬相关治疗靶点提供依据。
