Banat's University of Agricultural Sciences and Veterinary Medicine "King Michael I of Romania" from Timisoara, Romania.
Facultad de Ciencias de la Salud, Universidad Arturo Prat, Avda. Arturo Prat 2120, Iquique 1110939, Chile.
Biomed Pharmacother. 2022 Sep;153:113364. doi: 10.1016/j.biopha.2022.113364. Epub 2022 Jul 8.
Thymoquinone (TQ) is a secondary metabolite found in abundance in very few plant species including Nigella sativa L., Monarda fistulosa L., Thymus vulgaris L. and Satureja montana L. Preclinical pharmacological studies have shown that TQ has many biological activities, such as anti-inflammatory, antioxidant and anticancer. Both in vivo and in vitro experiments have shown that TQ acts as an antitumor agent by altering cell cycle progression, inhibiting cell proliferation, stimulating apoptosis, inhibiting angiogenesis, reducing metastasis and affecting autophagy. In this comprehensive study, the evidence on the pharmacological potential of TQ on pancreatic cancer is reviewed. The positive results of preclinical studies support the view that TQ can be considered as an additional therapeutic agent against pancreatic cancer. The possibilities of success for this compound in human medicine should be further explored through clinical trials.
姜酮（TQ）是一种次生代谢产物，在包括黑种草（Nigella sativa L.）、马郁兰（Monarda fistulosa L.）、普通麝香草（Thymus vulgaris L.）和山艾（Satureja montana L.）在内的极少数植物物种中含量丰富。临床前药理学研究表明，TQ 具有许多生物活性，如抗炎、抗氧化和抗癌作用。体内和体外实验均表明，TQ 通过改变细胞周期进程、抑制细胞增殖、刺激细胞凋亡、抑制血管生成、减少转移和影响自噬来发挥抗肿瘤作用。在这项全面的研究中，综述了 TQ 对胰腺癌的药理作用的证据。临床前研究的积极结果支持这样一种观点，即 TQ 可以被认为是一种治疗胰腺癌的附加治疗剂。应该通过临床试验进一步探索这种化合物在人类医学中的成功可能性。
