Kurowska Natalia, Madej Marcel, Strzalka-Mrozik Barbara
Department of Molecular Biology, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia, 40-055 Katowice, Poland.
Silesia LabMed, Centre for Research and Implementation, Medical University of Silesia, 40-752 Katowice, Poland.
Curr Issues Mol Biol. 2023 Dec 23;46(1):121-139. doi: 10.3390/cimb46010010.
Colorectal cancer (CRC) is one of the most commonly diagnosed cancers and is responsible for approximately one million deaths each year. The current standard of care is surgical resection of the lesion and chemotherapy with 5-fluorouracil (5-FU). However, of concern is the increasing incidence in an increasingly younger patient population and the ability of CRC cells to develop resistance to 5-FU. In this review, we discuss the effects of thymoquinone (TQ), one of the main bioactive components of seeds, on CRC, with a particular focus on the use of TQ in combination therapy with other chemotherapeutic agents. TQ exhibits anti-CRC activity by inducing a proapoptotic effect and inhibiting proliferation, primarily through its effect on the regulation of signaling pathways crucial for tumor progression and oxidative stress. TQ can be used synergistically with chemotherapeutic agents to enhance their anticancer effects and to influence the expression of signaling pathways and other genes important in cancer development. These data appear to be most relevant for co-treatment with 5-FU. We believe that TQ is a suitable candidate for consideration in the chemoprevention and adjuvant therapy for CRC, but further studies, including clinical trials, are needed to confirm its safety and efficacy in the treatment of cancer.
结直肠癌（CRC）是最常被诊断出的癌症之一，每年导致约100万人死亡。目前的标准治疗方法是对病变进行手术切除，并使用5-氟尿嘧啶（5-FU）进行化疗。然而，令人担忧的是，CRC在越来越年轻的患者群体中的发病率不断上升，以及CRC细胞对5-FU产生耐药性的能力。在本综述中，我们讨论了黑种草籽的主要生物活性成分之一百里醌（TQ）对CRC的影响，特别关注TQ与其他化疗药物联合治疗的应用。TQ主要通过影响对肿瘤进展和氧化应激至关重要的信号通路的调节，诱导促凋亡效应并抑制增殖，从而表现出抗CRC活性。TQ可与化疗药物协同使用，以增强其抗癌效果，并影响癌症发展中重要的信号通路和其他基因的表达。这些数据似乎与与5-FU联合治疗最为相关。我们认为TQ是CRC化学预防和辅助治疗中值得考虑的合适候选药物，但需要进一步的研究，包括临床试验，以确认其在癌症治疗中的安全性和有效性。
