Wnt 信号通路在骨改建能量代谢中的作用。
The role of the Wnt signalling pathway in the energy metabolism of bone remodelling.
机构信息
Laboratory of Molecular Signaling and Stem Cells Therapy, Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction, Capital Medical University School of Stomatology, Beijing, China.
Research Unit of Tooth Development and Regeneration, Chinese Academy of Medical Sciences, Beijing, China.
出版信息
Cell Prolif. 2022 Nov;55(11):e13309. doi: 10.1111/cpr.13309. Epub 2022 Jul 10.
OBJECTIVES
Bone remodelling is necessary to repair old and impaired bone caused by aging and its effects. Injury in the process of bone remodelling generally leads to the development of various bone diseases. Energy metabolism plays crucial roles in bone cell formation and function, the disorder of which will disrupt the balance between bone formation and bone resorption.
MATERIALS AND METHODS
Here, we review the intrinsic interactions between bone remodelling and energy metabolism and the role of the Wnt signalling pathway.
RESULTS
We found a close interplay between metabolic pathways and bone homeostasis, demonstrating that bone plays an important role in the regulation of energy balance. We also discovered that Wnt signalling is associated with multiple biological processes regulating energy metabolism in bone cells.
CONCLUSIONS
Thus, targeted regulation of Wnt signalling and the recovery of the energy metabolism function of bone cells are key means for the treatment of metabolic bone diseases.
目的
骨骼重塑是修复因衰老及其影响而导致的陈旧性和受损骨骼所必需的。在骨骼重塑过程中发生的损伤通常会导致各种骨骼疾病的发展。能量代谢在骨细胞的形成和功能中起着至关重要的作用，其紊乱会破坏骨形成和骨吸收之间的平衡。
材料与方法
在这里，我们回顾了骨骼重塑和能量代谢之间的内在相互作用，以及 Wnt 信号通路的作用。
结果
我们发现代谢途径和骨骼动态平衡之间存在密切的相互作用，表明骨骼在调节能量平衡方面起着重要作用。我们还发现，Wnt 信号与调节骨细胞能量代谢的多种生物学过程有关。
结论
因此，靶向调节 Wnt 信号和恢复骨细胞的能量代谢功能是治疗代谢性骨疾病的关键手段。
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