Xu Wenchao, Jiang Hongyang, Liu Jihong, Li Hao
Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Institute of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Front Mol Biosci. 2022 Jun 22;9:888624. doi: 10.3389/fmolb.2022.888624. eCollection 2022.
Erectile dysfunction (ED) is a common sexual dysfunction in males, with multifactorial alterations which consist of psychological and organic. Diabetes mellitus (DM) induced erectile dysfunction (DMED) is a disconcerting and critical complication of DM, and remarkably different from non-diabetic ED. The response rate of phosphodiesterase type 5 inhibitor (PDE5i), a milestone for ED therapy, is far from satisfactory in DMED. Unfortunately, the contributing mechanisms of DMED remains vague. Hence, It is urgent to seek for novel prospective biomarkers or targets of DMED. Numerous studies have proved that non-coding RNAs (ncRNAs) play essential roles in the pathogenesis process of DM, which comprise of long non-coding RNAs (lncRNAs) and small non-coding RNAs (sncRNAs) like microRNAs (miRNAs), PIWI-interacting RNAs (piRNAs) and circular RNAs (circRNAs). However, the implications of ncRNAs in DMED are still understudied. This review highlights the pathophysiology of DMED, summarizes identified mechanisms of ncRNAs associated with DMED and covers the topic of perspectives for ncRNAs in DMED.
勃起功能障碍（ED）是男性常见的性功能障碍，其由心理和器质性等多因素改变引起。糖尿病（DM）所致勃起功能障碍（DMED）是糖尿病令人困扰且严重的并发症，与非糖尿病性ED有显著差异。5型磷酸二酯酶抑制剂（PDE5i）作为ED治疗的一个里程碑，其在DMED中的有效率远不尽人意。遗憾的是，DMED的发病机制仍不明确。因此，迫切需要寻找DMED新的潜在生物标志物或靶点。大量研究证明，非编码RNA（ncRNAs）在糖尿病发病过程中起重要作用，包括长链非编码RNA（lncRNAs）和微小RNA（miRNAs）、PIWI相互作用RNA（piRNAs）及环状RNA（circRNAs）等小非编码RNA（sncRNAs）。然而，ncRNAs在DMED中的作用仍研究不足。本综述重点介绍了DMED的病理生理学，总结了已确定的与DMED相关的ncRNAs机制，并探讨了ncRNAs在DMED中的研究前景。
