Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Shenzhen Huazhong University of Science and Technology Research Institute, Shenzhen, Guangdong, China.
Front Endocrinol (Lausanne). 2023 Mar 9;14:1123383. doi: 10.3389/fendo.2023.1123383. eCollection 2023.
Erectile dysfunction (ED), as a common male disease, can seriously reduce the life quality of men and their partners. With the improvement of human living standards, ED is considered to be an important health issue that plagues men. However, it is difficult for existing therapeutic approaches to meet the needs of all patients, so it is necessary to develop novel treatment strategies. Exosomes, as a class of vesicles secreted by cells with bilayer membrane structure, are involved in various physiological and pathological processes in human body and considered to have great therapeutic potentials. This review summarizes the recent advances on exosome therapy with animal models of ED, and proposes the prospect of future research in order to provide a basis for clinical trials and clinical translation.
勃起功能障碍（ED）作为一种常见的男性疾病，可严重降低男性及其伴侣的生活质量。随着人类生活水平的提高，ED 被认为是困扰男性的一个重要健康问题。然而，现有的治疗方法很难满足所有患者的需求，因此有必要开发新的治疗策略。外泌体是一类由具有双层膜结构的细胞分泌的囊泡，参与人体的各种生理和病理过程，被认为具有巨大的治疗潜力。本文综述了外泌体治疗 ED 动物模型的最新进展，并提出了未来研究的展望，以期为临床试验和临床转化提供依据。
