Gillies D R, Littlewood J M, Sarsfield J K
Clin Allergy. 1987 Mar;17(2):105-11. doi: 10.1111/j.1365-2222.1987.tb02327.x.
Twenty-six asthmatic children participated in a controlled trial of house dust mite avoidance. Group A (n = 14) had 12 weeks' avoidance, provided that they had not deteriorated at the end of the first 6 weeks. Group B (n = 12) had an initial 6 weeks' observation period followed by 6 weeks' avoidance. Mite numbers were extremely variable and often low. There was a significant fall in mite numbers in the first, but not the second, 6-week period in group A. In group B there was a significant fall in mite numbers in both the first (observation) and second (active avoidance) periods. Active avoidance produced highly significant falls in total serum IgE. There were no significant changes in IgE during the observation period. This impressive immunological effect was not associated with any changes in the radio-allergo-sorbent assay (RAST) to house dust mite, or symptom scores; peak expiratory flow rates or histamine induced bronchial reactivity. More rigorous avoidance procedures in more severely affected asthmatic patients warrants further investigation.
26名哮喘儿童参与了一项避免接触屋尘螨的对照试验。A组（n = 14）进行为期12周的避免接触措施，前提是在前6周结束时病情未恶化。B组（n = 12）先有6周的观察期，随后是6周的避免接触期。螨数量变化极大且通常很低。A组在第一个6周期间螨数量显著下降，但在第二个6周期间没有。B组在第一个（观察）和第二个（主动避免接触）期间螨数量均显著下降。主动避免接触使总血清IgE大幅下降。在观察期内IgE没有显著变化。这种令人印象深刻的免疫效应与针对屋尘螨的放射变应原吸附试验（RAST）、症状评分、呼气峰值流速或组胺诱导的支气管反应性的任何变化均无关。对病情更严重的哮喘患者采用更严格的避免接触程序值得进一步研究。
