Harving H, Korsgaard J, Dahl R
Department of Respiratory Diseases, Aarhus University Hospital, Denmark.
Allergy. 1994 Dec;49(10):866-70. doi: 10.1111/j.1398-9995.1994.tb00789.x.
In temperate climates, energy-conserving measures may increase indoor humidity, enhancing house-dust mite (HDM) growth. Movement of families to "healthy" homes with mechanical ventilation systems reduced HDM exposure. The effect on asthma control of moving to the "healthy" homes was studied in 14 asthmatic patients allergic to HDM. Base-line evaluations of lung function, asthma symptoms, and medication requirements were made before moving and again after 5 and 15 months' residence. A control group of 11 mite-sensitive asthmatic patients who did not move were examined contemporaneously with the study group at base line and at the first follow-up investigation. After 5 months, the residents of the "healthy" homes improved in forced expiratory volume in 1 s (FEV1), medicine score, and serum IgE. These changes were significantly different from control group measurements. After 15 months, statistically significant improvements from base line were found in FEV1, average daily peak expiratory flow values, medicine score, symptom score, and serum IgE. Insignificant trends toward improvement were seen in provocation concentration of histamine and blood eosinophils. A significant relation was found between reduction in medicine score and fall in HDM exposure. The present study shows that a specific HDM-avoidance procedure can result in an overall, clinical improvement in HDM-sensitive asthmatic patients.
在温带气候地区，节能措施可能会增加室内湿度，促进屋尘螨（HDM）生长。家庭搬入配备机械通风系统的“健康”住宅后，接触HDM的情况减少。本研究对14名对HDM过敏的哮喘患者，探讨了搬入“健康”住宅对哮喘控制的影响。在搬家前以及居住5个月和15个月后，分别对患者的肺功能、哮喘症状和药物需求进行了基线评估。同时，选取11名未搬家的螨敏感哮喘患者作为对照组，在基线和首次随访调查时与研究组同步进行检查。5个月后，“健康”住宅的居住者在1秒用力呼气量（FEV1）、药物评分和血清IgE方面有所改善。这些变化与对照组的测量结果有显著差异。15个月后，FEV1、平均每日呼气峰值流速、药物评分、症状评分和血清IgE较基线有统计学意义的显著改善。组胺激发浓度和血液嗜酸性粒细胞数量虽有改善趋势，但不显著。药物评分的降低与HDM暴露量的下降之间存在显著关联。本研究表明，特定的HDM规避措施可使HDM敏感哮喘患者的整体临床状况得到改善。
