Department of Endocrinology and Metabolism, Affiliated Hospital of Weifang Medical University, Weifang, China; Department of Pathology, Affiliated Hospital of Weifang Medical University, Weifang, China; Branch of Shandong Provincial Clinical Research Center for Diabetes and Metabolic Diseases, and Clinical Research Center, Affiliated Hospital of Weifang Medical University, Weifang, China.
Department of Endocrinology and Metabolism, Affiliated Hospital of Weifang Medical University, Weifang, China; Branch of Shandong Provincial Clinical Research Center for Diabetes and Metabolic Diseases, and Clinical Research Center, Affiliated Hospital of Weifang Medical University, Weifang, China.
Pathol Res Pract. 2022 Aug;236:154013. doi: 10.1016/j.prp.2022.154013. Epub 2022 Jul 5.
Collagen type I alpha 1 (COL1A1), a member of the collagen family, is involved in epithelial-mesenchymal transition, which is closely linked to malignant tumorigenesis. COL1A1 is highly expressed in various cancers and regulates various cellular processes, including cell proliferation, metastasis, apoptosis, and cisplatin resistance. COL1A1 is also associated with cancer progression and prognosis; elevated COL1A1 expression is associated with poor prognosis in cancer patients. However, the main role of COL1A as a cancer-promoting factor in specific tumors has not been reported. Additionally, the protein levels and mechanisms of action of this protein differ among tumor types. This review discusses current research progress concerning COL1A1 in different tumor types, and then summarizes its contributions to cancer progression, thus providing a basis for follow-up research and potential targets for cancer treatment.
胶原类型 I 阿尔法 1（COL1A1）是胶原家族的一员，参与上皮-间充质转化，这与恶性肿瘤的发生密切相关。COL1A1 在各种癌症中高表达，并调节多种细胞过程，包括细胞增殖、转移、凋亡和顺铂耐药性。COL1A1 还与癌症的进展和预后有关；癌症患者中 COL1A1 表达水平升高与预后不良有关。然而，COL1A 作为特定肿瘤中促进癌症的主要因子的作用尚未得到报道。此外，这种蛋白在不同肿瘤类型中的蛋白水平和作用机制也不同。本综述讨论了 COL1A1 在不同肿瘤类型中的研究进展，然后总结了其对癌症进展的贡献，为后续的研究和癌症治疗的潜在靶点提供了依据。
