Carreira P E, Mateo I, Garcia G, Garrido G, Gomez-Reino J
Clin Rheumatol. 1987 Mar;6(1):80-3. doi: 10.1007/BF02201006.
We studied the frequency of antibodies to extractable cellular antigens in 90 Spanish SLE patients. Antibodies to Sm, nRNP, Ro and La were found, respectively, in 6 (6.6%), 18 (20%), 30 (33.3%) and 6 (6.6%) patients. In spite of HLA differences, these results are similar to those found by other authors in Caucasian SLE patients. Our only relevant association was the finding of severe renal disease and high frequency of anti-DNA and hypocomplementemia in patients with antibodies to Ro. Based on these and earlier findings, we discuss the possibility that the immune response to Ro in Spanish patients might be located in a unique extended HLA-complement haplotype.
我们研究了90例西班牙系统性红斑狼疮（SLE）患者中可提取性细胞抗原抗体的频率。分别在6例（6.6%）、18例（20%）、30例（33.3%）和6例（6.6%）患者中发现了抗Sm、抗nRNP、抗Ro和抗La抗体。尽管存在HLA差异，但这些结果与其他作者在白种人SLE患者中发现的结果相似。我们唯一相关的关联是，在抗Ro抗体阳性的患者中发现了严重肾病、抗DNA高频率以及低补体血症。基于这些及早期发现，我们讨论了西班牙患者对Ro的免疫反应可能位于独特的扩展HLA - 补体单倍型中的可能性。
