Moutsopoulos H M, Giotaki H, Maddison P J, Mavridis A C, Drosos A A, Skopouli F N
Ann Rheum Dis. 1984 Apr;43(2):285-7. doi: 10.1136/ard.43.2.285.
One hundred and twenty-four sera from Greek patients with autoimmune rheumatic diseases (29 with systemic lupus erythematosus (SLE), 24 with scleroderma, 11 with primary Sjögren's syndrome (SS), and 60 with rheumatoid arthritis (RA) were tested for antibodies to nRNP, Sm, Scl-70, Ro(SSA), and La(SSB) cellular antigens. The incidence of these antibodies in the different groups of patients examined, did not differ overall from that described previously. It was noted, however, that antibodies to Sm were very infrequently found in Greek patients with SLE and anti-Ro positive patients with SLE did not have the clinical manifestations described by other workers. Finally, it was found that anti-Ro positive patients with RA experienced a high frequency of side effects from penicillamine-D. The significance of these findings is discussed.
对124份来自患有自身免疫性风湿疾病的希腊患者的血清进行了检测，这些患者包括29例系统性红斑狼疮（SLE）患者、24例硬皮病患者、11例原发性干燥综合征（SS）患者以及60例类风湿关节炎（RA）患者，检测其针对nRNP、Sm、Scl - 70、Ro(SSA)和La(SSB)细胞抗原的抗体。在所检测的不同患者组中，这些抗体的发生率总体上与先前描述的无差异。然而，值得注意的是，希腊SLE患者中很少发现抗Sm抗体，且抗Ro阳性的SLE患者没有其他研究者所描述的临床表现。最后，发现抗Ro阳性的RA患者使用青霉胺 - D时出现副作用的频率很高。对这些发现的意义进行了讨论。
