Zhu Q F, Huang Y C
Zhonghua Zhong Liu Za Zhi. 1986 Nov;8(6):456-7.
10 patients with gastric carcinoma treated by HPD-laser preoperatively are reported. The gastric lesions were irradiated with laser beam delivered by a quartz fibre through the fiberoptic gastroscope 48-72 hours after intravenous injection of HPD (5.0 mg/kg) about 2 weeks before operation. In the resected specimens, the histological changes following HPD-laser therapy were studied. The cancer cells in the irradiated areas showed degeneration and necrosis in varying degrees. Because of the fact that the light spots were small and the penetration not deep enough, the cancer cells beyond the irradiated area and those infiltrating more deeply or beyond the gastric wall did not show any evident changes while metastatic cancers in the lymph nodes showed no changes at all. These facts may suggest that the HPD-laser therapy should not be used as the main therapeutic method to replace operation, radiotherapy or chemotherapy for gastric cancers in either advanced or early stage.
本文报道了10例术前接受血卟啉衍生物（HPD）-激光治疗的胃癌患者。术前约2周，静脉注射HPD（5.0mg/kg）后48-72小时，通过光纤胃镜经石英纤维传输激光束照射胃部病变。在切除标本中，研究了HPD-激光治疗后的组织学变化。照射区域的癌细胞呈现出不同程度的变性和坏死。由于光斑小且穿透不够深，照射区域以外、浸润更深或超出胃壁的癌细胞未显示任何明显变化，而淋巴结中的转移癌则完全没有变化。这些事实可能表明，HPD-激光治疗不应作为替代胃癌手术、放疗或化疗的主要治疗方法，无论胃癌处于晚期还是早期。
