高密度脂蛋白胆固醇水平与 COPD 患者或高危人群躯干肌肉缺陷和能量消耗减少的可能关联：一项初步研究。
Possible association of high-density lipoprotein cholesterol levels with trunk muscle deficits and decrease in energy expenditure in patients with or at risk for COPD: A pilot study.
机构信息
Department of Respiratory Medicine, Saitama Medical University, Saitama, Japan.
Department of Respiratory Medicine, Saitama Medical University, Saitama, Japan.
出版信息
Respir Investig. 2022 Sep;60(5):720-724. doi: 10.1016/j.resinv.2022.06.005. Epub 2022 Jul 9.
BACKGROUND
Chronic obstructive pulmonary disease (COPD) is associated with low muscle mass and function caused by malnutrition and physical inactivity. We aimed to investigate possible associations between serum biomarkers and clinical traits including computed tomography-derived muscle measurements and energy expenditure indices in COPD.
METHODS
Total energy expenditure (TEE) was measured by the doubly labeled water method, while physical activity level (PAL) was calculated as TEE/basal metabolic rate. Cross-sections and densities of pectoralis, rectus abdominis, and erector spinae muscles were measured. Serum biomarkers included adiponectin, insulin-like growth factor-1, and high-density lipoprotein (HDL)- and low-density lipoprotein (LDL)-cholesterol (C).
RESULTS
HDL-C levels were significantly correlated with all muscle areas, densities, and TEE. Only LDL-C levels were correlated with PAL.
CONCLUSIONS
HDL-C level was a potential biomarker for trunk muscle volumes and functions, as well as total energy expenditure in COPD.
背景
慢性阻塞性肺疾病（COPD）与营养不良和身体活动不足导致的肌肉减少和功能障碍有关。我们旨在研究 COPD 患者血清生物标志物与临床特征（包括 CT 衍生的肌肉测量和能量消耗指数）之间可能存在的关联。
方法
总能量消耗（TEE）通过双标记水法测量，而体力活动水平（PAL）则计算为 TEE/基础代谢率。胸肌、腹直肌和竖脊肌的横截面积和密度均有测量。血清生物标志物包括脂联素、胰岛素样生长因子-1 和高密度脂蛋白（HDL）-和低密度脂蛋白（LDL）-胆固醇（C）。
结果
HDL-C 水平与所有肌肉面积、密度和 TEE 均呈显著相关。仅 LDL-C 水平与 PAL 相关。
结论
HDL-C 水平是 COPD 患者躯干肌肉体积和功能以及总能量消耗的潜在生物标志物。
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