Gervais A, Nanji A A, Greenway D C, McLean W
Drug Intell Clin Pharm. 1987 May;21(5):450-2. doi: 10.1177/106002808702100515.
Falsely elevated serum digoxin values have recently been reported in patients with liver disease. Since not all patients have circulatory digoxin-like immunoreactive substance (DLIS) in their serum, we compared the clinical and laboratory findings in patients with and without DLIS. Thirty-two patients with liver disease were studied. The only parameter that was significantly different in the two groups was serum bilirubin. In the group of patients with DLIS, significant correlations were obtained between DLIS and bilirubin and DLIS and creatinine. We postulate that increased levels of DLIS in serum are due to an abnormality of DLIS excretion.
最近有报道称，肝病患者的血清地高辛值会出现假性升高。由于并非所有患者血清中都存在循环的地高辛样免疫反应物质（DLIS），我们比较了有和没有DLIS的患者的临床和实验室检查结果。对32例肝病患者进行了研究。两组之间唯一有显著差异的参数是血清胆红素。在有DLIS的患者组中，DLIS与胆红素以及DLIS与肌酐之间存在显著相关性。我们推测，血清中DLIS水平升高是由于DLIS排泄异常所致。
