Friedman H S, Babb B, Shim I B, Sotomora G, Farrer S M, Vasavada B C
Section of Cardiology, Brooklyn Hospital Center.
Chest. 1993 Mar;103(3):878-81. doi: 10.1378/chest.103.3.878.
To determine the relation between urinary digoxin-like immunoreactive substance (DLIS) and cardiac performance.
Cohort study.
Echocardiography laboratory of a university-affiliated teaching hospital.
Thirty-four individuals referred for echocardiographic studies who had never received cardiac glycosides or other substances known to cross-react with a digoxin radioimmunoassay and had no condition that has been associated with increased DLIS.
Cardiac dimensions and indices of cardiac performance derived from echocardiograms and cardiac Doppler flow studies and concentrations of urinary DLIS, creatinine, and electrolytes.
Urinary DLIS ranged from < 0.125 ng (digoxin equivalents) per milliliter (below the sensitivity of the assay) to 0.99 ng/ml, averaging 0.22 +/- 0.24 ng/ml. On bivariate analyses, UDLIS was found to correlate significantly with body weight, left ventricular (LV) end-diastolic dimension, LV fractional shortening, mitral transvalvular flow velocity following atrial systole, and urinary calcium. On multivariate analyses, the association between urinary DLIS (alone or adjusted for urinary creatinine) and LV fractional shortening emerged as the paramount independent relation.
Urinary DLIS can be related to cardiac performance under steady-state conditions. This suggests that DLIS may be a ligand for a cardiac glycoside receptor.
确定尿中地高辛样免疫反应物质（DLIS）与心脏功能之间的关系。
队列研究。
一所大学附属医院的超声心动图实验室。
34名因超声心动图检查前来就诊的个体，他们从未接受过强心苷或其他已知会与地高辛放射免疫分析发生交叉反应的物质，且没有与DLIS升高相关的疾病。
从超声心动图和心脏多普勒血流研究中得出的心脏尺寸和心脏功能指标，以及尿中DLIS、肌酐和电解质的浓度。
尿中DLIS的范围为每毫升<0.125纳克（地高辛当量）（低于检测灵敏度）至0.99纳克/毫升，平均为0.22±0.24纳克/毫升。在双变量分析中，发现尿中DLIS与体重、左心室（LV）舒张末期内径、LV缩短分数、心房收缩后二尖瓣跨瓣流速以及尿钙显著相关。在多变量分析中，尿中DLIS（单独或校正尿肌酐后）与LV缩短分数之间的关联成为最重要的独立关系。
在稳态条件下，尿中DLIS可能与心脏功能有关。这表明DLIS可能是强心苷受体的配体。
