Hodge Francesca, Bajuszova Viktoria, van Oosten-Hawle Patricija
Astbury Centre for Structural Molecular Biology, Faculty of Biological Sciences, School of Molecular and Cellular Biology, University of Leeds, Leeds, United Kingdom.
Front Aging. 2022 Jun 2;3:897741. doi: 10.3389/fragi.2022.897741. eCollection 2022.
In multicellular organisms such as , cellular stress stimuli and responses are communicated between tissues to promote organismal health- and lifespan. The nervous system is the predominant regulator of cell nonautonomous proteostasis that orchestrates systemic stress responses to integrate both internal and external stimuli. This review highlights the role of the intestine in mediating cell nonautonomous stress responses and explores recent findings that suggest a central role for the intestine to regulate organismal proteostasis. As a tissue that receives and further transduces signals from the nervous system in response to dietary restriction, heat- and oxidative stress, and hypoxia, we explore evidence suggesting the intestine is a key regulatory organ itself. From the perspective of naturally occurring stressors such as dietary restriction and pathogen infection we highlight how the intestine can function as a key regulator of organismal proteostasis by integrating insulin/IGF-like signaling, miRNA-, neuropeptide- and metabolic signaling to alter distal tissue functions in promoting survival, health- and lifespan.
在诸如多细胞生物中，细胞应激刺激和反应在组织之间传递，以促进机体健康和寿命。神经系统是细胞非自主蛋白质稳态的主要调节者，它协调全身应激反应以整合内部和外部刺激。本综述强调了肠道在介导细胞非自主应激反应中的作用，并探讨了最近的研究结果，这些结果表明肠道在调节机体蛋白质稳态中起着核心作用。作为一个接收并进一步转导来自神经系统的信号以应对饮食限制、热应激、氧化应激和缺氧的组织，我们探讨了表明肠道本身是一个关键调节器官的证据。从饮食限制和病原体感染等自然应激源的角度出发，我们强调肠道如何通过整合胰岛素/胰岛素样生长因子信号、微小RNA、神经肽和代谢信号来改变远端组织功能，从而在促进生存、健康和寿命方面作为机体蛋白质稳态的关键调节者发挥作用。
