State Key Laboratory of Food Science and Technology, China-Canada Joint Lab of Food Science and Technology (Nanchang), Key laboratory of Bioactive Polysaccharides of Jiangxi Province, Nanchang University, Nanchang, China.
Key Laboratory of Coarse Cereal Processing (Ministry of Agriculture and Rural Affairs), School of Food and Biological Engineering, Chengdu University, Chengdu, China.
Crit Rev Food Sci Nutr. 2023 Nov;63(33):12073-12088. doi: 10.1080/10408398.2022.2098249. Epub 2022 Jul 12.
Firmicutes and Bacteroidetes are the predominant bacterial phyla colonizing the healthy human gut. Accumulating evidence suggests that dietary fiber plays a crucial role in host health, yet most studies have focused on how the dietary fiber affects health through gut Bacteroides. More recently, gut Firmicutes have been found to possess many genes responsible for fermenting dietary fiber, and could also interact with the intestinal mucosa and thereby contribute to homeostasis. Consequently, the relationship between dietary fiber and Firmicutes is of interest, as well as the role of Firmicutes in host health. In this review, we summarize the current knowledge regarding the molecular mechanism of dietary fiber degradation by gut Firmicutes and explain the communication pathway of the dietary fiber-Firmicutes-host axis, and the beneficial effects of dietary fiber-induced Firmicutes and their metabolites on health. A better understanding of the dialogue sustained by the dietary fiber-Firmicutes axis and the host could provide new insights into probiotic therapy and novel dietary interventions aimed at increasing the abundance of Firmicutes (such as , , and ) to promote health.
厚壁菌门和拟杆菌门是定植在健康人体肠道中的主要细菌门。越来越多的证据表明，膳食纤维在宿主健康中起着至关重要的作用，但大多数研究都集中在膳食纤维如何通过肠道拟杆菌影响健康。最近，人们发现肠道厚壁菌门拥有许多负责发酵膳食纤维的基因，它们还可以与肠黏膜相互作用，从而有助于维持体内平衡。因此，膳食纤维与厚壁菌门的关系以及厚壁菌门在宿主健康中的作用引起了人们的关注。在这篇综述中，我们总结了肠道厚壁菌门降解膳食纤维的分子机制的最新知识，并解释了膳食纤维-厚壁菌门-宿主轴的通讯途径，以及膳食纤维诱导的厚壁菌门及其代谢产物对健康的有益影响。更好地理解膳食纤维-厚壁菌门轴与宿主之间的对话，可以为益生菌治疗和旨在增加厚壁菌门（如 、 和 ）丰度以促进健康的新型饮食干预提供新的见解。
